Phosphocreatine resynthesis is not affected by creatine loading
Vandenberghe K, Van Hecke P, Van Leemputte M, Vanstapel F, Hespel P
Medicine and science in sports and exercise · 60 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 1999-02-01 · Med Sci Sports Exerc · vol. 31 · número 2 · págs. 236–242
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 103 citas · más que el 94% de estudios similares · 3.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 14 trabajos
- Acceso
- De pago
- Áreas de investigación
- Muscle metabolism and nutrition · Biochemical effects in animals · Sports Performance and Training
- Palabras clave
- creatine supplementation, creatine loading, phosphocreatine resynthesis, phosphocreatine breakdown, high-intensity intermittent exercise, isometric contraction, knee extension torque, ergogenic aids, gastrocnemius
- MeSH
- leg, muscle, skeletal, humans, creatine, phosphocreatine, adenosine triphosphate, magnetic resonance spectroscopy, analysis of variance, linear models, cross-over studies, double-blind method, energy metabolism, physical endurance, muscle contraction, torque, adolescent, adult, male
5 autores
- Katleen Vandenberghe🇧🇪KU Leuven
- Paul Van Hecke🇧🇪KU Leuven
- Marc Van Leemputte🇧🇪KU Leuven
- Florent J.L.A. Vanstapel🇧🇪KU Leuven
- Peter Hespel🇧🇪KU Leuven
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
Oral creatine supplementation has been shown to improve power output during high intensity intermittent muscle contractions. Facilitated muscle phosphocreatine (PCr) resynthesis, by virtue of elevated intracellular PCr concentration, might contribute to this ergogenic action. Therefore, the effect of creatine loading (C: 25 g X d(-1) for 5 d) on muscle PCr breakdown and resynthesis and muscle performance during high intensity intermittent muscle contractions was investigated.
Methods
A double-blind randomized cross-over study was performed in young healthy male volunteers (N = 9). 31P-NMR spectroscopy of the m. gastrocnemius and isokinetic dynamometry of knee-extension torque were performed before and after 2 and 5 d of either placebo (P) or C administration.
Results
Compared with P, 2 and 5 d of C increased (P < 0.05) resting muscle PCr concentration by 11% and 16%, respectively. Furthermore, torque production during maximal intermittent knee extensions, including the first bout of contractions, was increased (P < 0.05) by 5-13% by either 2 or 5 d of C. However, compared with P, the rate of PCr breakdown and resynthesis during intermittent isometric contractions of the calf was not significantly affected by C.
Conclusion
Creatine loading raises muscle PCr concentration and improves performance during rapid and dynamic intermittent muscle contractions. Creatine loading does not facilitate muscle PCr resynthesis during intermittent isometric muscle contractions.
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