The effect of dietary omega-3 fatty acids on coronary atherosclerosis. A randomized, double-blind, placebo-controlled trial
von Schacky C, Angerer P, Kothny W, Theisen K, Mudra H
Annals of internal medicine · 302 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 1999-04-06 · Ann Intern Med · vol. 130 · número 7 · págs. 554–562
- Editorial
- American College of Physicians
- Citado
- 487 citas · más que el 100% de estudios similares · 24.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 34 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Nutritional Studies and Diet · Aquaculture Nutrition and Growth
- Palabras clave
- omega-3 fatty acids, fish oil, coronary artery disease, eicosapentaenoic acid, docosahexaenoic acid, atherosclerosis regression, atherosclerosis progression, cardiovascular events, LDL cholesterol, dietary supplementation
- MeSH
- humans, disease progression, fatty acids, omega-3, placebos, coronary angiography, statistics, nonparametric, patient compliance, adult, middle aged, female, male, cholesterol, ldl, coronary artery disease
5 autores
- Clemens von Schacky🇩🇪 · autor de correspondenciaLudwig-Maximilians-Universität München
- Peter Angerer🇩🇪Ludwig-Maximilians-Universität München
- Wolfgang Kothny🇩🇪Ludwig-Maximilians-Universität München
- Karl Theisen🇩🇪Ludwig-Maximilians-Universität München
- Harald Mudra🇩🇪Ludwig-Maximilians-Universität München
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Epidemiologic studies, studies of mechanisms of action, and many animal studies indicate that dietary intake of omega-3 fatty acids has antiatherosclerotic potential. Few trials in humans have examined this potential.
Objective
To determine the effect of dietary intake of omega-3 fatty acids on the course of coronary artery atherosclerosis in humans.
Design
Randomized, double-blind, placebo-controlled, clinically controlled trial.
Setting
University preventive cardiology unit.
Patients
223 patients with angiographically proven coronary artery disease.
Intervention
Fish oil concentrate (55% eicosapentaenoic and docosahexaenoic acids) or a placebo with a fatty acid composition resembling that of the average European diet, 6 g/d for 3 months and then 3 g/d for 21 months.
Measurements
The results of standardized coronary angiography, done before and after 2 years of treatment, were evaluated by an expert panel (primary end point) and by quantitative coronary angiography. Patients were followed for clinical and laboratory status.
Results
Pairs of angiograms (one taken at baseline and one taken at 2 years) were evaluated for 80 of 112 placebo recipients and 82 of 111 fish oil recipients. At the end of treatment, 48 coronary segments in the placebo group showed changes (36 showed mild progression, 5 showed moderate progression, and 7 showed mild regression) and 55 coronary segments in the fish oil group showed changes (35 showed mild progression, 4 showed moderate progression, 14 showed mild regression, and 2 showed moderate regression) (P = 0.041). Loss in minimal luminal diameter, as assessed by quantitative coronary angiography, was somewhat less in the fish oil group (P > 0.1). Fish oil recipients had fewer cardiovascular events (P = 0.10); other clinical variables did not differ between the study groups. Low-density lipoprotein cholesterol levels tended to be greater in the fish oil group.
Conclusion
Dietary intake of omega-3 fatty acids modestly mitigates the course of coronary atherosclerosis in humans.
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