The effect of magnesium supplementation on biochemical markers of bone metabolism or blood pressure in healthy young adult females
Doyle L, Flynn A, Cashman K
European journal of clinical nutrition · 31 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 1999-04-01 · Eur J Clin Nutr · vol. 53 · número 4 · págs. 255–261
- Editorial
- Springer Nature
- Citado
- 44 citas · más que el 81% de estudios similares · 1.4× el promedio de su campo
- Referencias
- 49 trabajos
- Acceso
- De pago
- Áreas de investigación
- Magnesium in Health and Disease · Magnesium Alloys: Properties and Applications · Nutrition and Health Studies
- Palabras clave
- magnesium supplementation, dietary magnesium, blood pressure, bone metabolism, bone turnover, urinary magnesium excretion, erythrocyte magnesium, osteocalcin, bone-specific alkaline phosphatase, pyridinium crosslinks, bone resorption, young adult women
- MeSH
- humans, calcium, magnesium, creatinine, parathyroid hormone, alkaline phosphatase, amino acids, osteocalcin, enzyme-linked immunosorbent assay, chromatography, high pressure liquid, cross-over studies, double-blind method, bone remodeling, blood pressure, adult, female, biomarkers
3 autores
- Lorna Doyle🇮🇪University College Cork
- Albert Flynn🇮🇪University College Cork
- Kevin D. Cashman🇮🇪University College Cork
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
To investigate the effects of increasing Mg intakes, above the usual dietary intake, on blood pressure and on biomarkers of bone metabolism in healthy young adult females.
Design
A double-blind, placebo-controlled, randomised crossover Mg intervention trial.
Setting
The study was conducted in the Department of Nutrition, University College, Cork, Ireland.
Subjects
Twenty-six healthy (normotensive) adult females aged 20-28 y were recruited from University College, Cork.
Intervention
Subjects were randomly assigned to their self-selected diets (approximately 11 mmol Mg/d) or their self-selected diet with a 10 mmol/d Mg supplement as Mg(OH)2 (approximately 22 mmol Mg/d) for 28 d followed by cross-over to the alternative diet for a further 28 d. During each dietary period urines (last 3 d) and blood (morning of 27 d) were collected and blood pressure was measured on the morning of 28 d.
Results
Increasing Mg intake from the usual level (11 mmol/d) to 22 mmol/d for 28d increased urinary excretion of Mg by 36% and erythrocyte Mg content by 5% but had no effect on serum Mg, Ca, PTH, osteocalcin or bone-specific alkaline phosphatase (biomarkers of bone formation), urinary pyridinium crosslinks of collagen (biomarkers of bone resorption), or on blood pressure.
Conclusion
Increasing the mean Mg intake in healthy young adult females above the usual dietary intake, which is currently above the US EAR (estimated average requirement), but below the US RDA for Mg, does not affect blood pressure or the rate of bone turnover.
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