The association of bone mineral density with vitamin D receptor gene polymorphisms
Gong G, Stern HS, Cheng SC, Fong N, Mordeson J, Deng HW, Recker RR
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 94 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 1999-01-01 · Osteoporos Int · vol. 9 · número 1 · págs. 55–64
- Editorial
- Springer Science+Business Media
- Citado
- 161 citas · más que el 99% de estudios similares · 12.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 44 trabajos
- Acceso
- De pago
- Áreas de investigación
- Bone health and osteoporosis research · Vitamin D Research Studies · Genetic Associations and Epidemiology
- Palabras clave
- bone mineral density, VDR polymorphisms, genetic association, false positive rate, spinal bone mineral density, femoral neck bone mineral density, menopause, osteoporosis, genetic heterogeneity
- MeSH
- femur neck, spine, humans, receptors, calcitriol, age factors, menopause, bone density, phenotype, polymorphism, genetic, middle aged, female, male
7 autores
- G. Gong🇺🇸Creighton University
- Hal S. Stern🇺🇸Iowa State University
- Shih Cheng🇺🇸Creighton University
- Nelson Fong🇺🇸Creighton University
- John Nelson Mordeson🇺🇸Creighton University
- Hong‐Wen Deng🇺🇸Creighton University
- Robert R. Recker🇺🇸Creighton University
Resumen
El texto original del estudio, en el idioma en que se publicó.
A recent meta-analysis of 16 publications suggested that bone mineral density (BMD) is not associated with vitamin D receptor (VDR) gene polymorphism (VDRGP) at the 0.05 significance level when a study with genotyping mistakes is excluded. We wished to determine whether 'positive' findings supporting the BMD-VDRGP association may be explained by chance, and what factors affect the outcomes of these studies. Seventy-five articles and abstracts on the association of VDRGP with BMD and related skeletal phenotypes published before January 1997 were identified. Twenty-three of 67 (34.3%) studies on spinal BMD and 22 of 51 (43.1%) on femoral neck BMD had found a BMD-VDRGP association at p < 0.05, significantly (p = 7 x 10(-14) for spinal BMD, p = 9 x 10(-16) for hip BMD) higher than the expected 5% false positive rate under the null hypothesis of 'no association'. 'Positive' results were more frequently observed in studies on females before the menopause than those on females after the menopause (p < 0.02) or on male and female subjects combined (p < 0.05) when skeletal phenotypes at any bone sites were considered. The 'positive rate' among studies was also influenced by the age range of subjects studied and by the inclusion of subjects with osteoporosis. It is concluded that: (1) BMD is associated with VDRGP with high levels of confidence and (2) non-genetic factors and genetic heterogeneity interfere with the detection of the effects of VDRGP on bone phenotypes.
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