Oral magnesium supplementation inhibits platelet-dependent thrombosis in patients with coronary artery disease
Shechter M, Merz CN, Paul-Labrador M, Meisel SR, Rude RK, Molloy MD, Dwyer JH, Shah PK, Kaul S
The American journal of cardiology · 76 citas
Etiquetas de revisión
Financiación no declaradaSolo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 1999-07-01 · Am J Cardiol · vol. 84 · número 2 · págs. 152–156
- Editorial
- Elsevier BV
- Citado
- 111 citas · más que el 89% de estudios similares · 2.5× el promedio de su campo
- Referencias
- 26 trabajos
- Acceso
- De pago
- Áreas de investigación
- Platelet Disorders and Treatments · Magnesium in Health and Disease · Antiplatelet Therapy and Cardiovascular Diseases
- Palabras clave
- oral magnesium supplementation, magnesium oxide, coronary artery disease, aspirin, platelet aggregation, P-selectin, procoagulant activity, adhesion molecules, stable coronary artery disease
- MeSH
- blood platelets, monocytes, humans, coronary disease, coronary thrombosis, magnesium, magnesium oxide, lipids, antacids, cross-over studies, double-blind method, dietary supplements, aged, female, male
9 autores
- Michael Shechter🇺🇸 · autor de correspondenciaCedars-Sinai Medical Center
- C. Noel Bairey Merz🇺🇸Cedars-Sinai Medical Center; University of California, Los Angeles
- Maura J. Paul-Labrador🇺🇸Cedars-Sinai Medical Center; University of California, Los Angeles
- Simcha Ron Meisel🇺🇸Cedars-Sinai Medical Center; University of California, Los Angeles
- Robert K. Rude🇺🇸University of Southern California; Orthopaedic Hospital
- Mia D. Molloy🇺🇸Cedars-Sinai Medical Center
- James H. Dwyer🇺🇸University of Southern California
- Prediman K. Shah🇺🇸Cedars-Sinai Medical Center; University of California, Los Angeles
- Sanjay Kaul🇺🇸Cedars-Sinai Medical Center; University of California, Los Angeles
Resumen
El texto original del estudio, en el idioma en que se publicó.
The use of magnesium in the treatment of acute myocardial infarction remains controversial despite preliminary experimental evidence that magnesium plays a beneficial role as a regulator of thrombosis. This study examines whether oral magnesium treatment inhibits platelet-dependent thrombosis (PDT) in patients with coronary artery disease (CAD). In a randomized prospective, double-blind, crossover, and placebo-controlled study, 42 patients with CAD (37 men, 5 women, mean age 68 +/- 9 years) on aspirin received either magnesium oxide tablets (800 to 1,200 mg/day) or placebo for 3 months (phase 1) followed by a 4-week wash-out period, and the crossover treatment for 3 months (phase 2). PDT, platelet aggregation, platelet P-selectin flow cytometry, monocyte tissue factor procoagulant activity (TF-PCA), and adhesion molecule density were assessed before and after each phase. PDT was evaluated by an ex vivo perfusion model using the Badimon chamber. Median PDT was significantly reduced by 35% in patients who received magnesium versus placebo (delta change from baseline -24 vs 26 mm2/mm; p = 0.02, respectively). There was no significant effect of magnesium treatment on platelet aggregation, P-selectin expression, monocyte TF-PCA, or adhesion molecules. Oral magnesium treatment inhibited PDT in patients with stable CAD. This effect appears to be independent of platelet aggregation or P-selectin expression, and is evident despite aspirin therapy. These findings suggest a potential mechanism whereby magnesium may beneficially alter outcomes in patients with CAD.
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