A comparison of bowel preparations for flexible sigmoidoscopy: oral magnesium citrate combined with oral bisacodyl, one hypertonic phosphate enema, or two hypertonic phosphate enemas
Fincher RK, Osgard EM, Jackson JL, Strong JS, Wong RK
The American journal of gastroenterology · 17 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 1999-08-01 · Am J Gastroenterol · vol. 94 · número 8 · págs. 2122–2127
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 22 citas · más que el 71% de estudios similares · 0.8× el promedio de su campo
- Referencias
- 16 trabajos
- Acceso
- De pago
- Áreas de investigación
- Colorectal Cancer Screening and Detection · Gastrointestinal Bleeding Diagnosis and Treatment · Gastrointestinal motility and disorders
- Palabras clave
- bowel preparation, flexible sigmoidoscopy, magnesium citrate, bisacodyl, preparation quality, patient tolerance, diarrhea, diverticulum, polyps
- MeSH
- humans, colonic polyps, phosphates, citric acid, organometallic compounds, bisacodyl, cathartics, sigmoidoscopy, administration, oral, single-blind method, adult, aged, middle aged, female, male
5 autores
- Roger Keith Fincher🇺🇸 · autor de correspondenciaWalter Reed National Military Medical Center
- Eric M. Osgard🇺🇸Walter Reed National Military Medical Center
- Jeffrey L. Jackson🇺🇸Walter Reed National Military Medical Center
- Jeffrey Strong
- Roy K.H. Wong🇺🇸Walter Reed National Military Medical Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Magnesium citrate with hypertonic enemas or oral bisacodyl provides superior preparation quality for sigmoidoscopy over enemas alone. We compared three magnesium citrate sigmoidoscopy preparations in a randomized, single-blind, controlled trial.
Methods
Two hundred and ninety-one adults scheduled for routine sigmoidoscopy were randomly assigned to receive one of three preparations containing oral magnesium citrate (296 cc) taken the night before the procedure in combination with the following: 1) oral bisacodyl (10 mg), given with the magnesium citrate the night before the procedure; 2) one hypertonic phosphate enema 1 h before the procedure; or 3) two hypertonic phosphate enemas, given singly at 2 and 1 h before the procedure. Endoscopists rated preparation quality, procedure duration, and depth of endoscopic insertion. Patients assessed preparation comfort and overall satisfaction.
Results
Preparation quality was rated as excellent or good for 80.6% in the bisacodyl group, 88.7% in the one-enema group, and 85.1% in the two-enema group (p = 0.30). Patients reported the oral bisacodyl regimen was better tolerated (p = 0.032). Although the three regimens were comparable in most side effects, the bisacodyl preparation was associated with more diarrhea (p = 0.0003). Mean procedure duration, mean insertion depth, and prevalence of diverticula and polyps were similar in all groups. Fewer than 4% of patients required repeat procedures due to poor preparation quality.
Conclusions
There was no statistical difference between the quality of the three bowel preparations. Patients considered an oral bisacodyl and magnesium citrate regimen more easily tolerated, though it was associated with more diarrhea.
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