Performance and muscle fiber adaptations to creatine supplementation and heavy resistance training
Volek JS, Duncan ND, Mazzetti SA, Staron RS, Putukian M, Gómez AL, Pearson DR, Fink WJ, Kraemer WJ
Medicine and science in sports and exercise · 188 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 1999-08-01 · Med Sci Sports Exerc · vol. 31 · número 8 · págs. 1147–1156
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 366 citas · más que el 96% de estudios similares · 5.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 32 trabajos
- Acceso
- De pago
- Áreas de investigación
- Muscle metabolism and nutrition · Sports Performance and Training · Biochemical effects in animals
- Palabras clave
- creatine supplementation, high-load resistance training, muscle fiber hypertrophy, muscle fiber cross-sectional area, fat-free mass, body mass, physical performance, bench press, squatting, training quality, periodized resistance training
- MeSH
- muscle, skeletal, humans, hypertrophy, creatine, exercise, double-blind method, adaptation, physiological, body composition, dietary supplements, adult, male, muscle fibers, skeletal
9 autores
- Jeff S. Volek🇺🇸Pennsylvania State University
- Noel D. Duncan🇺🇸🇦🇺Pennsylvania State University; The University of Melbourne; Ball State University; Ohio University
- SCOTT A. MAZZETTI🇺🇸🇦🇺Pennsylvania State University; The University of Melbourne; Ball State University; Ohio University
- Robert S. Staron🇺🇸🇦🇺Pennsylvania State University; The University of Melbourne; Ball State University; Ohio University
- Margot Putukian🇺🇸🇦🇺Pennsylvania State University; The University of Melbourne; Ball State University; Ohio University
- A L. G mez
- DAVID R. PEARSON🇺🇸🇦🇺Pennsylvania State University; The University of Melbourne; Ball State University; Ohio University
- William J. Fink🇺🇸🇦🇺Pennsylvania State University; The University of Melbourne; Ball State University; Ohio University
- William J. Kraemer🇺🇸🇦🇺Pennsylvania State University; The University of Melbourne; Ball State University; Ohio University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
The purpose of this study was to examine the effect of creatine supplementation in conjunction with resistance training on physiological adaptations including muscle fiber hypertrophy and muscle creatine accumulation.
Methods
Nineteen healthy resistance-trained men were matched and then randomly assigned in a double-blind fashion to either a creatine (N = 10) or placebo (N = 9) group. Periodized heavy resistance training was performed for 12 wk. Creatine or placebo capsules were consumed (25 g x d(-1)) for 1 wk followed by a maintenance dose (5 g x d(-1)) for the remainder of the training.
Results
After 12 wk, significant (P < or = 0.05) increases in body mass and fat-free mass were greater in creatine (6.3% and 6.3%, respectively) than placebo (3.6% and 3.1%, respectively) subjects. After 12 wk, increases in bench press and squat were greater in creatine (24% and 32%, respectively) than placebo (16% and 24%, respectively) subjects. Compared with placebo subjects, creatine subjects demonstrated significantly greater increases in Type I (35% vs 11%), IIA (36% vs 15%), and IIAB (35% vs 6%) muscle fiber cross-sectional areas. Muscle total creatine concentrations were unchanged in placebo subjects. Muscle creatine was significantly elevated after 1 wk in creatine subjects (22%), and values remained significantly greater than placebo subjects after 12 wk. Average volume lifted in the bench press during training was significantly greater in creatine subjects during weeks 5-8. No negative side effects to the supplementation were reported.
Conclusion
Creatine supplementation enhanced fat-free mass, physical performance, and muscle morphology in response to heavy resistance training, presumably mediated via higher quality training sessions.
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