Docosahexaenoic acid but not eicosapentaenoic acid lowers ambulatory blood pressure and heart rate in humans
Mori TA, Bao DQ, Burke V, Puddey IB, Beilin LJ
Hypertension (Dallas, Tex. : 1979) · 244 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- U.S. Department of Commerce
- Gobierno
- National Institutes of Health
- Gobierno
- Medical Research Council
- Gobierno
- National Health and Medical Research Council
Según 4 financiadores declarados.
Publicación
- Publicado
- 1999-08-01 · Hypertension · vol. 34 · número 2 · págs. 253–260
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 407 citas · más que el 99% de estudios similares · 11.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 42 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Blood Pressure and Hypertension Studies · Eicosanoids and Hypertension Pharmacology
- Palabras clave
- docosahexaenoic acid, eicosapentaenoic acid, omega-3 fatty acids, fish oil supplementation, ambulatory blood pressure, heart rate, blood pressure reduction, hyperlipidemia, plasma phospholipid fatty acids, olive oil placebo, overweight men, nocturnal blood pressure, daytime blood pressure
- MeSH
- humans, body weight, potassium, sodium, creatinine, dietary fats, unsaturated, docosahexaenoic acids, eicosapentaenoic acid, fatty acids, phospholipids, plant oils, placebos, blood pressure monitoring, ambulatory, data interpretation, statistical, double-blind method, energy intake, blood pressure, heart rate, time factors, adult, aged, middle aged, male, hyperlipidemias, olive oil
5 autores
- Trevor Anthony Mori🇦🇺The University of Western Australia
- Danny Q. Bao🇦🇺The University of Western Australia
- Valerie Burke🇦🇺The University of Western Australia
- Ian B. Puddey🇦🇺The University of Western Australia
- Lawrence Joseph Beilin🇦🇺The University of Western Australia
Resumen
El texto original del estudio, en el idioma en que se publicó.
Animal studies suggest that the 2 major omega3 fatty acids found in fish, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), may have differential effects on blood pressure (BP) and heart rate (HR). The aim of this study was to determine whether there were significant differences in the effects of purified EPA or DHA on ambulatory BP and HR in humans. In a double-blind, placebo-controlled trial of parallel design, 59 overweight, mildly hyperlipidemic men were randomized to 4 g/d of purified EPA, DHA, or olive oil (placebo) capsules and continued their usual diets for 6 weeks. Fifty-six subjects completed the study. Only DHA reduced 24-hour and daytime (awake) ambulatory BP (P<0.05). Relative to the placebo group, 24-hour BP fell 5.8/3.3 (systolic/diastolic) mm Hg and daytime BP fell 3.5/2.0 mm Hg with DHA. DHA also significantly reduced 24-hour, daytime, and nighttime (asleep) ambulatory HRs (P=0. 001). Relative to the placebo group, DHA reduced 24-hour HR by 3. 5+/-0.8 bpm, daytime HR by 3.7+/-1.2 bpm, and nighttime HR by 2. 8+/-1.2. EPA had no significant effect on ambulatory BP or HR. Supplementation with EPA increased plasma phospholipid EPA from 1. 66+/-0.07% to 9.83+/-0.06% (P<0.0001) but did not change DHA levels. Purified DHA capsules increased plasma phospholipid DHA levels from 4.00+/-0.27% to 10.93+/-0.62% (P<0.0001) and led to a small, nonsignificant increase in EPA (1.52+/-0.12% to 2.26+/-0.16%). Purified DHA but not EPA reduced ambulatory BP and HR in mildly hyperlipidemic men. The results of this study suggest that DHA is the principal omega3 fatty acid in fish and fish oils that is responsible for their BP- and HR-lowering effects in humans. These results have important implications for human nutrition and the food industry.
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