Long-term efficacy and safety of a new olive oil-based intravenous fat emulsion in pediatric patients: a double-blind randomized study
Goulet O, de Potter S, Antébi H, Driss F, Colomb V, Béréziat G, Alcindor LG, Corriol O, Le Brun A, Dutot G, Forget D, Perennec V, Ricour C
The American journal of clinical nutrition · 80 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 1999-09-01 · Am J Clin Nutr · vol. 70 · número 3 · págs. 338–345
- Editorial
- Elsevier BV
- Citado
- 132 citas · más que el 88% de estudios similares · 2.3× el promedio de su campo
- Referencias
- 67 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Clinical Nutrition and Gastroenterology · Fatty Acid Research and Health · Central Venous Catheters and Hemodialysis
- Palabras clave
- pediatric parenteral nutrition, long-chain triglycerides, monounsaturated fatty acids, polyunsaturated fatty acids, erythrocyte membrane fatty acid composition, lipid peroxidation, cholesterol, apolipoproteins
- MeSH
- humans, dietary fats, unsaturated, fat emulsions, intravenous, plant oils, parenteral nutrition, double-blind method, child, child, preschool, infant, female, male, olive oil
13 autores
- Olivier Goulet🇫🇷 · autor de correspondenciaHôpital Necker-Enfants Malades; Hôpital Saint-Antoine
- Sophie De Potter🇫🇷Hôpital Necker-Enfants Malades; Hôpital Saint-Antoine
- H. Antébi🇫🇷Hôpital Necker-Enfants Malades; Hôpital Saint-Antoine
- Fathi Driss🇫🇷Hôpital Necker-Enfants Malades; Hôpital Saint-Antoine
- V. Colomb🇫🇷Hôpital Necker-Enfants Malades; Hôpital Saint-Antoine
- Gilbert Bereziat🇫🇷Hôpital Necker-Enfants Malades; Hôpital Saint-Antoine
- Louis‐Gérald Alcindor🇫🇷Hôpital Necker-Enfants Malades; Hôpital Saint-Antoine
- Odile Corriol🇫🇷Hôpital Necker-Enfants Malades; Hôpital Saint-Antoine
- Alexia Le Brun🇫🇷Hôpital Necker-Enfants Malades; Hôpital Saint-Antoine
- Guy Dutot🇫🇷Hôpital Necker-Enfants Malades; Hôpital Saint-Antoine
- Dominique Forget🇫🇷Hôpital Necker-Enfants Malades; Hôpital Saint-Antoine
- V. Pérennec🇫🇷Hôpital Necker-Enfants Malades; Hôpital Saint-Antoine
- C. Ricour🇫🇷Hôpital Necker-Enfants Malades; Hôpital Saint-Antoine
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
A new intravenous lipid emulsion (ILE) prepared from a mixture of soybean and olive oils contains only long-chain triacylglycerols, with a low proportion (20%) of polyunsaturated fatty acids and 60% monounsaturated fatty acids.
Objective
The goal of this randomized, double-blind clinical trial was to assess in children the efficacy and safety of this new ILE compared with a control group receiving a soybean-oil emulsion.
Design
Eighteen children received for 2 mo 24% of nonprotein energy (1.80 g kg (-)(1) d(-)(1)) either as the new ILE or a soybean oil-based emulsion. Assessments were performed on days -30, 0, 30, and 60 and the changes (day 60 - day 0) assessed by analysis of variance.
Results
There were no significant differences in triacylglycerol, apolipoproteins A-I and B, or HDL cholesterol between the 2 groups, whereas total and LDL cholesterol were higher in the soybean oil group on day 60. The pattern of 20:4n-6 in erythrocyte membranes did not change significantly, nor did the ratio of 20:3n-9 to 20:4n-6. On day 60, 18:1n-9 was significantly higher in the olive oil group, the ratio of Sigma(n)-6 > C(18) + 18:3n-6 to 18:2n-6 was 2.20 +/- 0.09 in the olive oil group and 1.33 +/- 0.16 in the soybean-oil group, and Sigma(n)-3 > C(18) was 3.83 +/- 0.30 in the olive oil group and 4. 03 +/- 0.33 in the soybean-oil group. The peroxidation index was lower after the olive oil treatment.
Conclusions
The olive oil-based emulsion was well tolerated, maintained a normal EFA status, and may be more suitable for prevention of lipid peroxidation than the soybean-oil-based emulsion.
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