A prospective, randomized clinical trial on perioperative feeding with an arginine-, omega-3 fatty acid-, and RNA-enriched enteral diet: effect on host response and nutritional status
Gianotti L, Braga M, Fortis C, Soldini L, Vignali A, Colombo S, Radaelli G, Di Carlo V
JPEN. Journal of parenteral and enteral nutrition · 98 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 1999-11-01 · JPEN J Parenter Enteral Nutr · vol. 23 · número 6 · págs. 314–320
- Editorial
- Wiley
- Citado
- 170 citas · más que el 98% de estudios similares · 9.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 47 trabajos
- Acceso
- De pago
- Áreas de investigación
- Clinical Nutrition and Gastroenterology · Enhanced Recovery After Surgery · Infant Nutrition and Health
- Palabras clave
- immunonutrition, L-arginine, omega-3 fatty acids, cytokine response, IL-2 receptor alpha, interleukin-6, prealbumin, retinol-binding protein, delayed-type hypersensitivity, cell-mediated immunity, nutritional status, gastric cancer, colorectal cancer
- MeSH
- humans, gastrointestinal neoplasms, fatty acids, omega-3, arginine, rna, cytokines, enteral nutrition, prospective studies, double-blind method, nutritional status, adolescent, adult, aged, middle aged, female, male
8 autores
- Luca Vittorio Gianotti🇮🇹IRCCS Ospedale San Raffaele
- Marco Braga🇮🇹IRCCS Ospedale San Raffaele
- Claudio Fortis🇮🇹IRCCS Ospedale San Raffaele
- Laura Soldini🇮🇹IRCCS Ospedale San Raffaele
- Andrea Vignali🇮🇹IRCCS Ospedale San Raffaele
- Stefania Colombo🇮🇹IRCCS Ospedale San Raffaele
- Giovanni Radaelli🇮🇹University of Milan
- Valerio Di Carlo🇮🇹IRCCS Ospedale San Raffaele
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The use of immune-enhancing enteral diets in the postoperative period has given contrasting results. The purpose of this prospective, randomized, double-blinded clinical study was to evaluate the effect of immunonutrition given perioperatively on cytokine release and nutritional parameters.
Methods
Patients with cancer of the stomach or colo-rectum were eligible. Subjects consumed 1 L/d of either a control enteral formula (n = 25; control group) or a formula supplemented with arginine, omega-3 fatty acids, and RNA (n = 25; verum group) for 1 week before surgery. Both formulas were given by mouth. Six hours after the operation, jejunal infusion with the same diets was started and maintained for 7 days. Blood was drawn at different time points to assess albumin, prealbumin (PA), transferrin, cholinesterase activity, retinol binding protein (RBP), interleukin-2 receptors alpha (IL-2Ralpha), IL-6, and IL-1 soluble receptors (IL-1RII). The composite score of delayed hypersensitivity response (DHR) to skin test also was determined (the higher the score, the lower the immune response).
Results
During the 7 days of presurgical feeding, none of the above parameters changed in either group. Eight days after operation, in the control group, the concentration of PA and RBP was lower than in the verum group (0.18 vs 0.26 g/L for PA and 30.5 vs 38.7 mg/L for RBP; p < .05). IL-2Ralpha concentration was 507 pg/mL in the verum group vs 238 pg/mL in the control group (p < .001), whereas IL-6 and IL-1RII were higher in the control group than in the verum group (104 vs 49 and 328 vs 183 pg/mL, respectively; p < .01). The DHR score was 0.68 in the control group vs 0.42 in the verum group (p < .05).
Conclusions
Perioperative feeding with a supplemented enteral diet modulates cytokine production and enhances cell-mediated immunity and the synthesis of short half-life proteins.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.