Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans
Dulloo AG, Duret C, Rohrer D, Girardier L, Mensi N, Fathi M, Chantre P, Vandermander J
The American journal of clinical nutrition · 524 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 1999-12-01 · Am J Clin Nutr · vol. 70 · número 6 · págs. 1040–1045
- Editorial
- Elsevier BV
- Citado
- 924 citas · más que el 97% de estudios similares · 6.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 29 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Tea Polyphenols and Effects · Coffee research and impacts · Adipose Tissue and Metabolism
- Palabras clave
- green tea extract, catechins, epigallocatechin gallate, caffeine, energy expenditure, fat oxidation, thermogenesis, respiratory quotient, norepinephrine, urinary catecholamines, urinary nitrogen, weight management, functional foods, sympathetic nervous system
- MeSH
- adipose tissue, humans, obesity, catechin, caffeine, central nervous system stimulants, plant extracts, energy metabolism, oxidation-reduction, circadian rhythm, tea, adult, male, lipid metabolism
8 autores
- Abdul G. Dulloo🇨🇭🇫🇷 · autor de correspondenciaUniversity of Geneva; University Hospital of Geneva; Arkopharma (France)
- Claudette Duret🇨🇭🇫🇷University of Geneva; University Hospital of Geneva; Arkopharma (France)
- Dorothée Rohrer🇨🇭🇫🇷University of Geneva; University Hospital of Geneva; Arkopharma (France)
- Lucien Girardier🇨🇭🇫🇷University of Geneva; University Hospital of Geneva; Arkopharma (France)
- Nouri Mensi🇨🇭🇫🇷University of Geneva; University Hospital of Geneva; Arkopharma (France)
- Marc Fathi🇨🇭🇫🇷University of Geneva; University Hospital of Geneva; Arkopharma (France)
- Philippe Chantre🇨🇭🇫🇷University of Geneva; University Hospital of Geneva; Arkopharma (France)
- Jacques Vandermander🇨🇭🇫🇷University of Geneva; University Hospital of Geneva; Arkopharma (France)
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Current interest in the role of functional foods in weight control has focused on plant ingredients capable of interfering with the sympathoadrenal system.
Objective
We investigated whether a green tea extract, by virtue of its high content of caffeine and catechin polyphenols, could increase 24-h energy expenditure (EE) and fat oxidation in humans.
Design
Twenty-four-hour EE, the respiratory quotient (RQ), and the urinary excretion of nitrogen and catecholamines were measured in a respiratory chamber in 10 healthy men. On 3 separate occasions, subjects were randomly assigned among 3 treatments: green tea extract (50 mg caffeine and 90 mg epigallocatechin gallate), caffeine (50 mg), and placebo, which they ingested at breakfast, lunch, and dinner.
Results
Relative to placebo, treatment with the green tea extract resulted in a significant increase in 24-h EE (4%; P < 0.01) and a significant decrease in 24-h RQ (from 0.88 to 0.85; P < 0.001) without any change in urinary nitrogen. Twenty-four-hour urinary norepinephrine excretion was higher during treatment with the green tea extract than with the placebo (40%, P < 0.05). Treatment with caffeine in amounts equivalent to those found in the green tea extract had no effect on EE and RQ nor on urinary nitrogen or catecholamines.
Conclusions
Green tea has thermogenic properties and promotes fat oxidation beyond that explained by its caffeine content per se. The green tea extract may play a role in the control of body composition via sympathetic activation of thermogenesis, fat oxidation, or both.
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