Effect of docosahexaenoic acid supplementation of lactating women on the fatty acid composition of breast milk lipids and maternal and infant plasma phospholipids
Jensen CL, Maude M, Anderson RE, Heird WC
The American journal of clinical nutrition · 110 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Eye Institute
- Gobierno
- NEI NIH HHS
- Subvenciones
- National Eye Institute (EY04149); National Eye Institute (EY 00871)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2000-01-01 · Am J Clin Nutr · vol. 71 · número 1 · págs. 292S–299S
- Editorial
- Elsevier BV
- Citado
- 207 citas · más que el 96% de estudios similares · 6.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 58 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Infant Nutrition and Health · Breastfeeding Practices and Influences
- Palabras clave
- docosahexaenoic acid, DHA supplementation, lactating women, breast milk fatty acid composition, breastfeeding, marine oils, omega-6 fatty acids
- MeSH
- milk, human, humans, docosahexaenoic acids, fatty acids, triglycerides, phospholipids, fish oils, chromatography, gas, chromatography, thin layer, breast feeding, lactation, dietary supplements, eggs, adult, infant, female
4 autores
- Craig L. Jensen🇺🇸Baylor College of Medicine; Children's Nutrition Research Center at Baylor College of Medicine
- Maureen B. Maude
- Robert E. Anderson
- William C. Heird
Resumen
El texto original del estudio, en el idioma en que se publicó.
To determine whether docosahexaenoic acid (DHA) supplementation of breast-feeding mothers increases the DHA contents of breast milk and infant plasma phospholipids (PPs), breast-feeding women were randomly assigned to 3 DHA-supplementation groups (170-260 mg/d) or a control group. Group 1 (n = 6) consumed an algae-produced high-DHA triacylglycerol; group 2 (n = 6) consumed high-DHA eggs; group 3 (n = 6) consumed a high-DHA, low-eicosapentaenoic acid marine oil; and group 4 (n = 6) received no supplementation. From before to after supplementation (2 and 8 wk postpartum), mean (+/-SD) maternal PP DHA increased in groups 1, 2, and 3 by 1.20 +/- 0.53, 0.63 +/- 0.82, and 0.76 +/- 0.35 mol% of fatty acids, respectively (23-41%), but decreased in group 4 by 0.44 +/- 0.34 mol% (15%). Breast-milk DHA of groups 1, 2, and 3 increased by 0.21 +/- 0.16, 0.07 +/- 0.11, and 0. 12 +/- 0.07 mol%, respectively (32-91%) but decreased in group 4 by 0.03 +/- 0.04 mol% (17%). Mean infant PP DHA in groups 1, 2, and 3 increased by 1.63 +/- 0.79, 0.40 +/- 1.0, and 0.98 +/- 0.61 mol%, respectively (11-42%), but only by 0.18 +/- 0.74 mol% (5%) in group 4. Correlations between the DHA contents of maternal plasma and breast milk and of milk and infant PPs were significant. Breast-milk and maternal and infant PP 22:5n-6 concentrations were lowest in group 2. DHA supplementation increases the plasma and breast-milk DHA concentrations of lactating women, resulting in higher PP DHA concentrations in infants.
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