Cholesterol-lowering effects of psyllium intake adjunctive to diet therapy in men and women with hypercholesterolemia: meta-analysis of 8 controlled trials
Anderson JW, Allgood LD, Lawrence A, Altringer LA, Jerdack GR, Hengehold DA, Morel JG
The American journal of clinical nutrition · 151 citas
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2000-02-01 · Am J Clin Nutr · vol. 71 · número 2 · págs. 472–479
- Editorial
- Elsevier BV
- Citado
- 338 citas · más que el 93% de estudios similares · 3.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 47 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Lipoproteins and Cardiovascular Health · Food composition and properties · Natural Products and Biological Research
- Palabras clave
- psyllium, hypercholesterolemia, LDL cholesterol, total cholesterol, soluble dietary fiber, low-fat diet, dietary supplementation, hypolipidemic effect, safety and tolerability, coronary heart disease prevention
- MeSH
- humans, hypercholesterolemia, lipids, triglycerides, psyllium, combined modality therapy, age factors, sex factors, adult, aged, aged, 80 and over, middle aged, female, male, cholesterol, ldl, cholesterol, hdl, controlled clinical trials as topic, hypolipidemic agents
7 autores
- James W. Anderson🇺🇸University of Kentucky; Veterans Health Administration; Lexington VA Health Care System
- Lisa D Allgood🇺🇸University of Kentucky; Lexington VA Health Care System; Procter & Gamble (United States)
- Ann Lawrence🇺🇸University of Kentucky; Lexington VA Health Care System; Procter & Gamble (United States)
- L. A. Altringer🇺🇸University of Kentucky; Lexington VA Health Care System; Procter & Gamble (United States)
- George R. Jerdack🇺🇸University of Kentucky; Lexington VA Health Care System; Procter & Gamble (United States)
- David A. Hengehold🇺🇸University of Kentucky; Lexington VA Health Care System; Procter & Gamble (United States)
- Jorge G. Morel🇺🇸University of Kentucky; Lexington VA Health Care System; Procter & Gamble (United States)
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Soluble fibers, including those from psyllium husk, have been shown to augment the cholesterol-lowering effects of a low-fat diet in persons with hypercholesterolemia. As evidence of this, the US Food and Drug Administration recently authorized the use of health claims on food products containing soluble fiber from psyllium that state that they are associated with a decreased risk of coronary heart disease.
Objective
This meta-analysis was conducted to more precisely define the hypolipidemic effects and safety of psyllium when used adjunctive to a low-fat diet in men and women with hypercholesterolemia.
Design
The 8 studies in the meta-analysis included a total of 384 and 272 subjects receiving psyllium or cellulose placebo, respectively. All studies evaluated the hypocholesterolemic effects of 10.2 g psyllium/d adjunctive to a low-fat diet for >/=8 wk in individuals with mild-to-moderate hypercholesterolemia after a low-fat diet lead-in phase lasting >/=8 wk. The safety and adverse events associated with psyllium consumption were summarized from pooled data of 19 clinical studies ranging from 6 wk to 6 mo in duration.
Results
Consumption of 10.2 g psyllium/d lowered serum total cholesterol by 4% (P < 0.0001), LDL cholesterol by 7% (P < 0.0001), and the ratio of apolipoprotein (apo) B to apo A-I by 6% (P < 0.05) relative to placebo in subjects already consuming a low-fat diet, with no effect on serum HDL or triacylglycerol concentrations.
Conclusions
Psyllium supplementation significantly lowered serum total and LDL-cholesterol concentrations in subjects consuming a low-fat diet. Psyllium is well tolerated and safe when used adjunctive to a low-fat diet in individuals with mild-to-moderate hypercholesterolemia.
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