Caffeine withdrawal increases cerebral blood flow velocity and alters quantitative electroencephalography (EEG) activity
Jones HE, Herning RI, Cadet JL, Griffiths RR
Psychopharmacology · 41 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- U.S. Public Health Service
- Gobierno
- National Institute on Drug Abuse
- Gobierno
- NIDA NIH HHS
- Subvenciones
- National Institute on Drug Abuse (R01 DA03890); National Institute on Drug Abuse (T32-DA07209)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2000-01-10 · Psychopharmacology (Berl) · vol. 147 · número 4 · págs. 371–377
- Editorial
- Springer Science+Business Media
- Citado
- 64 citas · más que el 84% de estudios similares · 1.7× el promedio de su campo
- Referencias
- 23 trabajos
- Acceso
- De pago
- Áreas de investigación
- Coffee research and impacts · Sleep and Work-Related Fatigue · Migraine and Headache Studies
- Palabras clave
- caffeine withdrawal, cerebral blood flow velocity, quantitative EEG, middle cerebral artery, anterior cerebral artery, pulsatility index, theta power, concentration ability, headache
- MeSH
- anterior cerebral artery, middle cerebral artery, humans, substance withdrawal syndrome, caffeine, central nervous system stimulants, electroencephalography, double-blind method, affect, psychomotor performance, cerebrovascular circulation, adult, middle aged, female, male
4 autores
- Hendrée E. Jones🇺🇸Johns Hopkins University; Johns Hopkins Medicine
- Ronald I. Herning🇺🇸National Institutes of Health; National Institute on Drug Abuse
- Jean Lud Cadet🇺🇸National Institutes of Health; National Institute on Drug Abuse
- Roland R. Griffiths🇺🇸Johns Hopkins University; Johns Hopkins Medicine
Resumen
El texto original del estudio, en el idioma en que se publicó.
Rationale
Cessation of daily caffeine consumption produces a withdrawal syndrome comprised of subjective symptoms and functional impairment. Few controlled studies have examined the physiological effects of caffeine withdrawal.
Objective
The present study examined the effect of caffeine withdrawal on cerebral blood flow velocity and quantitative EEG.
Methods
Ten volunteers reporting moderate caffeine intake (mean 333 mg/day) participated in this double-blind study. Subjects completed several tests when maintaining their normal diet (baseline period) and during two 1-day periods during which they consumed caffeine-free diets and received capsules containing placebo (placebo test session) or caffeine (caffeine test session) in amounts equal to their baseline daily caffeine consumption. Blood flow velocity was determined for four arteries: right and left middle (MCA), and right and left anterior (ACA) cerebral arteries using pulsed transcranial Doppler sonography. EEG was recorded for 3 min from eight scalp sites while subjects sat, with eyes closed, in a sound-attenuated electronically shielded chamber. Subjective effects were assessed with questionnaires.
Results
Results showed an effect of the placebo (21-h withdrawal) condition compared to the caffeine condition. Placebo significantly increased the mean velocity, systolic velocity and diastolic velocity (cm/s) in all four cerebral arteries. In the MCA, the pulsatility index was significantly decreased following placebo. Placebo significantly increased EEG theta power. Placebo also produces subjective effect changes, including increases in heavy feelings in arms and legs and decreases in ability to concentrate. The caffeine and baseline conditions produced similar results on both the physiological and subjective measures.
Conclusion
Cessation of daily caffeine consumption produced changes in cerebral blood flow velocity and quantitative EEG. These changes may be related to classic caffeine withdrawal symptoms of headache, drowsiness and decreased alertness.
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