Dietary supplementation with marine omega-3 fatty acids improve systemic large artery endothelial function in subjects with hypercholesterolemia
Goodfellow J, Bellamy MF, Ramsey MW, Jones CJ, Lewis MJ
Journal of the American College of Cardiology · 223 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- British Heart Foundation
Según 1 financiador declarado.
Publicación
- Publicado
- 2000-02-01 · J Am Coll Cardiol · vol. 35 · número 2 · págs. 265–270
- Editorial
- Elsevier BV
- Citado
- 380 citas · más que el 100% de estudios similares · 23.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 40 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Cardiovascular Health and Disease Prevention · Nitric Oxide and Endothelin Effects
- Palabras clave
- marine omega-3 fatty acids, dietary supplementation, endothelial function, large artery function, hypercholesterolemia, flow-mediated dilation, brachial artery, triglycerides, endothelium-dependent dilation, endothelium-independent relaxation, nitroglycerin
- MeSH
- brachial artery, endothelium, vascular, humans, arteriosclerosis, hypercholesterolemia, cholesterol, fatty acids, omega-3, triglycerides, fish oils, ultrasonography, doppler, color, blood flow velocity, treatment outcome, prospective studies, double-blind method, vasodilation, middle aged, female, male
5 autores
- Jonathan Goodfellow🇬🇧 · autor de correspondenciaUniversity of Wales
- Michael Bellamy🇬🇧University of Wales
- Mark W. Ramsey🇬🇧University of Wales
- Christopher J.H Jones🇬🇧University of Wales
- Malcolm J. LEWIS🇬🇧University of Wales
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
This work was undertaken to determine whether dietary supplementation with marine omega-3 fatty acids improve systemic large artery endothelial function in subjects with hypercholesterolemia.
Background
Marine omega-3 fatty acids improve vascular function, but the underlying mechanism(s) are unclear. We studied the effects of marine omega-3 fatty acids on large artery endothelial function in subjects with hypercholesterolemia.
Methods
Hypercholesterolemic subjects with no other known cause for endothelial dysfunction were recruited to a prospective, placebo-controlled, randomized, double-blind, parallel-group study. Treatment with omega-3 fatty acids at a dose of 4 g/day (n = 15/group) was compared with placebo, at the beginning (day 0) and end (day 120) of a four-month treatment period. Endothelial function was assessed pre- and posttreatment by noninvasive ultrasonic vessel wall tracking of brachial artery flow-mediated dilation (FMD).
Results
Treatment with marine omega-3 fatty acids resulted in a significant improvement in FMD (0.05 +/- 0.12 to 0.12 +/- 0.07 mm, p < 0.05) and a significant reduction in triglycerides (2.07 +/- 1.13 to 1.73 +/- 0.95 mmol/liter, p < 0.05), whereas treatment with placebo resulted in no change in FMD (0.03 +/- 0.10 to 0.04 +/- 0.10 mm) or triglycerides (2.29 +/- 2.09 to 2.05 +/- 1.36 mmol/liter) (both p < 0.05 treated compared with control). Responses to sublingual glyceryl trinitrate were unchanged.
Conclusions
Marine omega-3 fatty acids improve large artery endothelium-dependent dilation in subjects with hypercholesterolemia without affecting endothelium-independent dilation.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.