Acute creatine loading increases fat-free mass, but does not affect blood pressure, plasma creatinine, or CK activity in men and women
Mihic S, MacDonald JR, McKenzie S, Tarnopolsky MA
Medicine and science in sports and exercise · 118 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2000-02-01 · Med Sci Sports Exerc · vol. 32 · número 2 · pág. 291
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 201 citas · más que el 97% de estudios similares · 6.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 23 trabajos
- Acceso
- De pago
- Áreas de investigación
- Muscle metabolism and nutrition · Biochemical effects in animals · Sports Performance and Training
- Palabras clave
- creatine monohydrate, fat-free mass, body composition, blood pressure, serum creatinine, creatine kinase, grip strength, sex differences
- MeSH
- humans, creatine, creatinine, hand strength, exercise, double-blind method, sex factors, body composition, blood pressure, dietary supplements, adult, female, male
4 autores
- S. Mihic🇨🇦McMaster University Medical Centre; McMaster University
- Jay R. MacDonald🇨🇦McMaster University Medical Centre; McMaster University
- SCOTT McKENZIE🇨🇦McMaster University Medical Centre; McMaster University
- Mark Andrew Tarnopolsky🇨🇦McMaster University Medical Centre; McMaster University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Unlabelled
Creatine monohydrate (CrM) administration may enhance high intensity exercise performance and increase body mass, yet few studies have examined for potential adverse effects, and no studies have directly considered potential gender differences.
Purpose
The purpose of this study was to examine the effect of acute creatine supplementation upon total and lean mass and to determine potential side effects in both men and women.
Methods
The effect of acute CrM (20 g x d(-1) x 5 d) administration upon systolic, diastolic, and mean BP, plasma creatinine, plasma CK activity, and body composition was examined in 15 men and 15 women in a randomized, double-blind experiment. Additionally, ischemic isometric handgrip strength was measured before and after CrM or placebo (PL).
Results
CrM did not affect blood pressure, plasma creatinine, estimated creatinine clearance, plasma CK activity, or handgrip strength (P > 0.05). In contrast, CrM significantly increased fat-free mass (FFM) and total body mass (P < 0.05) as compared with PL, with no changes in body fat. The observed mass changes were greater for men versus women.
Conclusions
These findings suggest that acute CrM administration does not affect blood pressure, renal function, or plasma CK activity, but increases FFM. The effect of CrM upon FFM may be greater in men as compared with that in women.
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