Oxidation of an oil rich in docosahexaenoic acid compared to linoleic acid in lactating women
Fidler N, Sauerwald T, Demmelmair H, Pohl A, Koletzko B
Annals of nutrition & metabolism · 3 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 1999-01-01 · Ann Nutr Metab · vol. 43 · número 6 · págs. 339–345
- Editorial
- Karger Publishers
- Citado
- 10 citas · más que el 84% de estudios similares · 1.7× el promedio de su campo
- Referencias
- 14 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Lipid metabolism and biosynthesis · Edible Oils Quality and Analysis
- Palabras clave
- docosahexaenoic acid, linoleic acid, fatty acid oxidation, lactating women, 13C-labeled fatty acids, fatty acid absorption, omega-3 fatty acids, omega-6 fatty acids
- MeSH
- humans, carbon dioxide, docosahexaenoic acids, linoleic acid, breath tests, double-blind method, oxidation-reduction, lactation, adult, female
5 autores
- Nataša Fidler Mis🇩🇪Ludwig-Maximilians-Universität München
- Thorsten U. Sauerwald🇩🇪Ludwig-Maximilians-Universität München
- Hans Demmelmair🇩🇪Ludwig-Maximilians-Universität München
- A. Pohl🇩🇪Ludwig-Maximilians-Universität München
- Berthold Viktor Koletzko🇩🇪Ludwig-Maximilians-Universität München
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
We studied the oxidation of an oil rich in docosahexaenoic acid (DHA; DHASCO((R))) in lactating mothers receiving a dietary DHA supplement or a placebo. The results were compared with the oxidation of linoleic acid.
Methods
Breast-feeding mothers received a dietary supplement (DHASCO; 200 mg DHA/day, n = 5) or a placebo (n = 5) for 14 days. Six weeks post partum all 10 mothers received a single dose of 2 mg/kg body weight uniformly (13)C-labeled DHASCO. In a previously reported study 6 mothers received 1 mg/kg body weight uniformly (13)C-labeled linoleic acid. Breath samples were collected over 48 h after tracer application. The total CO(2) production was measured by indirect calorimetry and the (13)C isotopic enrichment of labeled CO(2) by isotopic ratio mass spectrometry.
Results
The oxidation of (13)C-labeled DHASCO in the supplemented and placebo groups was similar. Maximal (13)C enrichment was reached earlier in the group receiving (13)C-DHASCO (median 1.0 vs. 3.0 h in the linoleic acid group). The cumulative (13)C recovery in breath was higher in the DHASCO versus the linoleic acid group until 10 h after tracer application and comparable thereafter.
Conclusions
The difference in oxidation of DHASCO versus linoleic acid after tracer ingestion might be partly due to a faster absorption and oxidation of shorter chain saturated fatty acids contained in DHASCO. The cumulative oxidation of DHASCO and linoleic acid 24 and 48 h after tracer ingestion is similar.
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