Plant sterol and stanol margarines and health

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Cómo se estudió

Diseño

Metaanálisis (indexado por PubMed)

Estudiado en

Personas

Resultado principal

Marcadores de salud y funcionamiento

Consumo medido con

No se indica

Quién lo pagó

Financiación

Financiación no declarada

Publicación

Publicado

2000-03-25 · BMJ · vol. 320 · número 7238 · págs. 861–864

Editorial

BMJ

Citado

720 citas · más que el 100% de estudios similares · 46.4× el promedio de su campo

Impacto

Entre el 10 % más citado de su campo

Referencias

31 trabajos

Acceso

Acceso abierto (copia en repositorio)

Áreas de investigación

Lipoproteins and Cardiovascular Health · Cholesterol and Lipid Metabolism · Natural Products and Biological Research

Palabras clave

phytosterols, plant stanols, margarine, cholesterol absorption, serum cholesterol, LDL cholesterol, heart disease prevention, primary prevention, flora

MeSH

humans, cardiovascular diseases, phytosterols, margarine, diet, intestinal absorption, adult, middle aged, costs and cost analysis, cholesterol, ldl

1 autor

• Matthew G. Law🇬🇧 · autor de correspondenciaSt Bartholomew's Hospital; Queen Mary University of London

Texto inicial

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A new polyunsaturated margarine with added plant stanols, Benecol, was introduced in several European countries last year, and a similar margarine with added plant sterols will be introduced under the Flora label later this year. These products lower serum concentrations of cholesterol, but they are expensive.1–14 In Great Britain the cost is about £2.50 ($4.00) for a 250 g tub compared with 60p for ordinary polyunsaturated margarine and 90p for butter. This article considers quantitatively the health aspects of adding plant sterols and stanols to margarines and other foods. #### Summary points Plant sterols and stanols reduce the absorption of cholesterol from the gut and so lower serum concentrations of cholesterol Plant sterols or stanols that have been esterified to increase their lipid solubilitycan be incorporated into foods The 2 g of plant sterol or stanol added to an average daily portion of margarine reduces serum concentrations of low density lipoprotein cholesterol by an average of 0.54 mmol/l in people aged 50-59, 0.43 mmol/l in those aged 40-49, and 0.33 mmol/l in those aged 30-39 A reduction in the risk of heart disease of about 25% would be expected for this reduction in low density lipoprotein cholesterol; this is larger than the effect that could be expected to be achieved by people reducing their intake of saturated fat The added costs of £70 per person per year will limit consumption; however, if stanols and sterols become cheaper, their introduction into the food chain will make them an important innovation in the primary prevention of heart disease Randomised trials included in this review were identified by a Medline search using the term “plant sterols.” Additional trials were identified from citations in these papers and in review articles. Other trials in children with familial hypercholesterolaemia were not included. Sterols are an essential …

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