Randomised clinical trials of fish oil supplementation in high risk pregnancies. Fish Oil Trials In Pregnancy (FOTIP) Team
Olsen SF, Secher NJ, Tabor A, Weber T, Walker JJ, Gluud C
BJOG : an international journal of obstetrics and gynaecology · 200 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Aarhus Universitet
- Universidad u hospital
- Aarhus Universitetshospital
- Gobierno
- European Commission
- Gobierno
- National Research Foundation
- Gobierno
- Danmarks Grundforskningsfond
- Universidad u hospital
- Odense Universitetshospital
- Universidad u hospital
- Rigshospitalet
- Universidad u hospital
- Hvidovre Hospital
Según 8 financiadores declarados.
Publicación
- Publicado
- 2000-03-01 · BJOG · vol. 107 · número 3 · págs. 382–395
- Editorial
- Wiley
- Citado
- 360 citas · más que el 99% de estudios similares · 13.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 62 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Pregnancy and preeclampsia studies · Birth, Development, and Health
- Palabras clave
- fish oil supplementation, omega-3 fatty acids, high-risk pregnancy, preterm birth, fetal growth restriction, gestational hypertension, twin pregnancy, preeclampsia, olive oil placebo
- MeSH
- humans, fetal growth retardation, pregnancy complications, cardiovascular, hypertension, fish oils, pregnancy outcome, delivery, obstetric, gestational age, pregnancy, pregnancy, high-risk, dietary supplements, female, obstetric labor, premature
6 autores
- Sjurdur Frodi Olsen🇩🇰 · autor de correspondenciaStatens Serum Institut
- Niels Jørgen Secher🇩🇰 · autor de correspondenciaAarhus University Hospital
- Ann Tabor🇩🇰Hvidovre Hospital
- Tom Weber🇩🇰Hvidovre Hospital
- James Johnston Walker🇬🇧St James's University Hospital
- Christian Nyfeldt Gluud🇩🇰Copenhagen University Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To test the postulated preventive effects of dietary n-3 fatty acids on pre-term delivery, intrauterine growth retardation, and pregnancy induced hypertension.
Design
In six multicentre trials, women with high risk pregnancies were randomly assigned to receive fish oil (Pikasol) or olive oil in identically-looking capsules from around 20 weeks (prophylactic trials) or 33 weeks (therapeutic trials) until delivery.
Setting
Nineteen hospitals in Europe.
Samples
Four prophylactic trials enrolled 232, 280, and 386 women who had experienced previous pre-term delivery, intrauterine growth retardation, or pregnancy induced hypertension respectively, and 579 with twin pregnancies. Two therapeutic trials enrolled 79 women with threatening pre-eclampsia and 63 with suspected intrauterine growth retardation.
Interventions
The fish oil provided 2.7 g and 6.1 g n-3 fatty acids/day in the prophylactic and therapeutic trials, respectively.
Main outcome measures
Preterm delivery, intrauterine growth retardation, pregnancy induced hypertension.
Results
Fish oil reduced recurrence risk of pre-term delivery from 33% to 21% (odds ratio 0.54 (95% CI 0.30 to 0.98)) but did not affect recurrence risks for the other outcomes (OR 1.26; 0.74 to 2.12 and 0.98; 0.63 to 1.53, respectively). In twin pregnancies, the risks for all three outcomes were similar in the two intervention arms (95% CI for the three odds ratios were 0.73 to 1.40, 0.90 to 1.52, and 0.83 to 2.32, respectively). The therapeutic trials detected no significant effects on pre-defined outcomes. In the combined trials, fish oil delayed spontaneous delivery (proportional hazards ratio 1.22; 1.07 to 1.39, P = 0.002).
Conclusions
Fish oil supplementation reduced the recurrence risk of pre-term delivery, but had no effect on pre-term delivery in twin pregnancies. Fish oil had no effect on intrauterine growth retardation and pregnancy induced hypertension, affecting neither recurrence risk nor risk in twin pregnancies.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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