Magnesium supplementation in pregnancy
Makrides M, Crowther CA
The Cochrane database of systematic reviews · 21 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2001-10-23 · Cochrane Database Syst Rev · número 2 · pág. CD000937
- Editorial
- Elsevier BV
- Citado
- 87 citas
- Referencias
- 21 trabajos
- Acceso
- De pago
- Áreas de investigación
- Magnesium in Health and Disease · Pregnancy and preeclampsia studies · Maternal and Neonatal Healthcare
- Palabras clave
- magnesium supplementation, pregnancy, preterm birth, low birth weight, small for gestational age, preeclampsia, antepartum hemorrhage, fetal growth restriction, birth weight
- MeSH
- humans, magnesium, pregnancy, dietary supplements, female
2 autores
- Maria Makrides🇦🇺🇨🇦Women's and Children's Hospital; Women's & Children's Health Research Institute; Women's and Children's Health Network; Women and Children’s Health Research Institute; The University of Adelaide
- Caroline Anne Crowther🇦🇺The University of Adelaide
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Many women, especially those from disadvantaged backgrounds, have intakes of magnesium below recommended levels. Magnesium supplementation during pregnancy may be able to reduce fetal growth retardation and pre-eclampsia, and increase birthweight.
Objectives
The objective of this review was to assess the effects of magnesium supplementation during pregnancy on maternal, neonatal and paediatric outcomes.
Search strategy
We searched the Cochrane Pregnancy and Childbirth Group trials register.
Selection criteria
Randomised and quasi-randomised trials of dietary magnesium supplementation during pregnancy.
Data collection and analysis
Suitability for inclusion and methodological quality were separately assessed by each reviewer. Data were independently extracted by two reviewers.
Main results
Six trials involving 2637 women were included. Only one of these trials was judged to be of high quality. Compared with placebo, oral magnesium treatment from before the 25th week of gestation was associated with a lower incidence of preterm birth (odds ratio 0.71, 95% confidence interval 0.52 to 0.95). There was also less maternal hospitalisation during pregnancy, fewer cases of antepartum haemorrhage, a lower incidence of low birthweight and small for gestational age infants. Poor quality trials are likely to have resulted in a bias favouring magnesium supplementation.
Reviewer's conclusions
There is not enough high quality evidence to show that dietary magnesium supplementation during pregnancy is beneficial.
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