Purified eicosapentaenoic and docosahexaenoic acids have differential effects on serum lipids and lipoproteins, LDL particle size, glucose, and insulin in mildly hyperlipidemic men
Mori TA, Burke V, Puddey IB, Watts GF, O'Neal DN, Best JD, Beilin LJ
The American journal of clinical nutrition · 417 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2000-05-01 · Am J Clin Nutr · vol. 71 · número 5 · págs. 1085–1094
- Editorial
- Elsevier BV
- Citado
- 588 citas · más que el 99% de estudios similares · 14.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 57 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Aquaculture Nutrition and Growth · Edible Oils Quality and Analysis
- Palabras clave
- eicosapentaenoic acid, docosahexaenoic acid, omega-3 fatty acids, hyperlipidemia, serum lipids, lipoproteins, HDL cholesterol, HDL2, LDL cholesterol, LDL particle size, triglycerides, glucose metabolism, insulin, platelet phospholipids, olive oil placebo, overweight men
- MeSH
- humans, hypercholesterolemia, cholesterol, insulin, blood glucose, lipids, docosahexaenoic acids, eicosapentaenoic acid, triglycerides, lipoproteins, centrifugation, density gradient, double-blind method, particle size, adult, aged, middle aged, male, cholesterol, ldl, cholesterol, hdl
7 autores
- Trevor Anthony Mori🇦🇺The University of Melbourne; The University of Western Australia; St Vincent's Hospital Melbourne
- Valerie Burke🇦🇺The University of Melbourne; The University of Western Australia; St Vincent's Hospital Melbourne
- Ian B. Puddey🇦🇺The University of Melbourne; The University of Western Australia; St Vincent's Hospital Melbourne
- Gerald F. Watts🇦🇺The University of Melbourne; The University of Western Australia; St Vincent's Hospital Melbourne
- David Norman O'Neal🇦🇺The University of Melbourne; The University of Western Australia; St Vincent's Hospital Melbourne
- James Donovan Best🇦🇺The University of Melbourne; The University of Western Australia; St Vincent's Hospital Melbourne
- Lawrence Joseph Beilin🇦🇺The University of Melbourne; The University of Western Australia; St Vincent's Hospital Melbourne
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Regular consumption of n-3 fatty acids of marine origin can improve serum lipids and reduce cardiovascular risk.
Objective
This study aimed to determine whether eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids have differential effects on serum lipids and lipoproteins, glucose, and insulin in humans.
Design
In a double-blind, placebo-controlled trial of parallel design, 59 overweight, nonsmoking, mildly hyperlipidemic men were randomly assigned to receive 4 g purified EPA, DHA, or olive oil (placebo) daily while continuing their usual diets for 6 wk.
Results
Fifty-six men aged 48.8 +/- 1.1 y completed the study. Relative to those in the olive oil group, triacylglycerols fell by 0.45 +/- 0.15 mmol/L ( approximately 20%; P = 0.003) in the DHA group and by 0.37 +/- 0.14 mmol/L ( approximately 18%; P = 0.012) in the EPA group. Neither EPA nor DHA had any effect on total cholesterol. LDL, HDL, and HDL(2) cholesterol were not affected significantly by EPA, but HDL(3) cholesterol decreased significantly (6.7%; P = 0.032). Although HDL cholesterol was not significantly increased by DHA (3. 1%), HDL(2) cholesterol increased by approximately 29% (P = 0.004). DHA increased LDL cholesterol by 8% (P = 0.019). Adjusted LDL particle size increased by 0.25 +/- 0.08 nm (P = 0.002) with DHA but not with EPA. EPA supplementation increased plasma and platelet phospholipid EPA but reduced DHA. DHA supplementation increased DHA and EPA in plasma and platelet phospholipids. Both EPA and DHA increased fasting insulin significantly. EPA, but not DHA, tended to increase fasting glucose, but not significantly so.
Conclusions
EPA and DHA had differential effects on lipids, fatty acids, and glucose metabolism in overweight men with mild hyperlipidemia.
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