Influence of caffeine on the frequency and perception of hypoglycemia in free-living patients with type 1 diabetes
Watson JM, Jenkins EJ, Hamilton P, Lunt MJ, Kerr D
Diabetes care · 34 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2000-04-01 · Diabetes Care · vol. 23 · número 4 · págs. 455–459
- Editorial
- American Diabetes Association
- Citado
- 54 citas · más que el 88% de estudios similares · 2.4× el promedio de su campo
- Referencias
- 0 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Diabetes Management and Research · Coffee research and impacts · Diabetes and associated disorders
- Palabras clave
- caffeine, type 1 diabetes, hypoglycemia, hypoglycemic symptoms, symptomatic hypoglycemia, glycemic control, cognitive function, reaction time, blood pressure, cerebral blood flow, middle cerebral artery blood flow velocity, lipid profile, HbA1c
- MeSH
- humans, diabetes mellitus, type 1, hypoglycemia, caffeine, blood glucose, placebos, cross-over studies, double-blind method, cognition, perception, sex characteristics, blood pressure, heart rate, cerebrovascular circulation, adult, female, male, surveys and questionnaires
5 autores
- J M Watson🇬🇧Royal Bournemouth Hospital
- E J Jenkins🇬🇧Royal Bournemouth Hospital
- Paul Hamilton🇬🇧Royal Bournemouth Hospital
- M J Lunt🇬🇧Royal Bournemouth Hospital
- David Kerr🇬🇧Royal Bournemouth Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To examine the influence of caffeine on the frequency and perception of hypoglycemia in "free-living" patients with type 1 diabetes.
Research design and methods
A total of 34 patients with type 1 diabetes were recruited for a prospective randomized placebo-controlled double-blind study. After a lead-in phase and while adhering to a low-caffeine diet, subjects were randomized to capsules containing either 200 mg caffeine or matched placebo with crossover at 3 months. Hypoglycemic episodes were monitored throughout with capillary blood glucose readings and a symptom questionnaire. During the study, measurements of blood pressure, middle cerebral artery blood velocity (a surrogate measure of cerebral blood flow), cognitive function (via a four-choice reaction time test), HbAlc levels, and lipid profiles were taken at the beginning and end of each phase.
Results
Throughout the study, no changes were evident regarding glycemic control or lipid profile. The number of symptomatic episodes was greater with caffeine (1.3 vs. 0.9 episodes/week; P < 0.03) and was associated with more intense warning symptoms (29 vs. 26 total symptom score; P < 0.05). For women, caffeine ingestion caused a modest pressor response (115 vs. 110 mmHg; P < 0.01). Four-choice reaction time improved slightly with caffeine supplementation (P < 0.05).
Conclusions
Ingestion of modest amounts of caffeine enhances the intensity of hypoglycemia warning symptoms in patients with type 1 diabetes without altering the prevailing standard of glycemic control or increasing the incidence of severe hypoglycemic episodes.
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