Creatine therapy in myophosphorylase deficiency (McArdle disease): a placebo-controlled crossover trial
Vorgerd M, Grehl T, Jager M, Muller K, Freitag G, Patzold T, Bruns N, Fabian K, Tegenthoff M, Mortier W, Luttmann A, Zange J, Malin JP
Archives of neurology · 93 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2000-07-01 · Arch Neurol · vol. 57 · número 7 · pág. 956
- Editorial
- American Medical Association
- Citado
- 150 citas · más que el 98% de estudios similares · 7.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 40 trabajos
- Acceso
- De pago
- Áreas de investigación
- Glycogen Storage Diseases and Myoclonus · Metabolism and Genetic Disorders · Muscle metabolism and nutrition
- Palabras clave
- creatine supplementation, creatine monohydrate, McArdle disease, myophosphorylase deficiency, exercise intolerance, phosphocreatine depletion, skeletal muscle function, 31P NMR, surface electromyography, force-time integral
- MeSH
- muscle, skeletal, humans, glycogen storage disease type v, creatine, creatine kinase, phosphocreatine, exercise test, electromyography, treatment outcome, magnetic resonance spectroscopy, administration, oral, drug administration schedule, cross-over studies, double-blind method, energy metabolism, exercise tolerance, adult, middle aged, child, female, male
13 autores
- Matthias Vorgerd🇩🇪BG University Hospital Bergmannsheil Bochum; Ruhr University Bochum
- Torsten Grehl
- M Jäger
- K Müller
- G Freitag
- Tanja Patzold
- Nicolaus Bruns
- K. Fábián
- Martin Tegenthoff
- Wilhelm Mortier
- Alwin Luttmann
- Jochen Zange
- J.-P. Malin
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To determine whether treatment with creatine can improve exercise intolerance in myophosphorylase deficiency (McArdle disease).
Design
Double-blind, placebo-controlled crossover study with oral creatine monohydrate supplementation.
Patients
Nine patients with biochemically and genetically proven McArdle disease were treated.
Intervention
Five days of daily high-dose creatine intake (150 mg/kg body weight) were followed by daily low-dose creatine intake (60 mg/kg). Each treatment phase with creatine or placebo lasted 5 weeks.
Main outcome measures
The effect of treatment was estimated at the end of each treatment phase by recording clinical scores, ergometer exercise test results, phosphorus 31 nuclear magnetic resonance spectroscopy, and surface electromyography.
Results
Of 9 patients, 5 reported improvement of muscle complaints with creatine. Force-time integrals (P =.03) and depletion of phosphocreatine (P =.04) increased significantly during ischemic exercise with creatine. Phosphocreatine depletion also increased significantly during aerobic exercise (P =.006). The decrease of median frequency in surface electromyograms during contraction was significantly larger (P =.03) with creatine.
Conclusion
This is the first controlled study indicating that creatine supplementation improves skeletal muscle function in McArdle disease.
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