ApoE polymorphism and fish oil supplementation in subjects with an atherogenic lipoprotein phenotype
Minihane AM, Khan S, Leigh-Firbank EC, Talmud P, Wright JW, Murphy MC, Griffin BA, Williams CM
Arteriosclerosis, thrombosis, and vascular biology · 159 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Directorate for Biological Sciences
- Gobierno
- Biotechnology and Biological Sciences Research Council
Según 2 financiadores declarados.
Publicación
- Publicado
- 2000-08-01 · Arterioscler Thromb Vasc Biol · vol. 20 · número 8 · págs. 1990–1997
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 215 citas · más que el 97% de estudios similares · 7.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 70 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Lipoproteins and Cardiovascular Health · Lipid metabolism and disorders
- Palabras clave
- APOE polymorphism, fish oil supplementation, eicosapentaenoic acid, docosahexaenoic acid, atherogenic lipoprotein phenotype, dyslipidemia, postprandial triglyceride response, HDL cholesterol, LDL cholesterol, lipoprotein lipase activity, APOE ε4 carriers, ApoE2 allele, olive oil placebo
- MeSH
- humans, arteriosclerosis, fatty acids, nonesterified, triglycerides, lipoproteins, fish oils, apolipoproteins e, placebos, fasting, cross-over studies, double-blind method, genotype, phenotype, polymorphism, genetic, food, adult, aged, middle aged, male, cholesterol, ldl, cholesterol, hdl
8 autores
- Anne Marie Minihane🇬🇧University of Surrey; University College London; University of Reading
- Syrah Khan🇬🇧University of Surrey; University College London; University of Reading
- Elizabeth C. Leigh-Firbank🇬🇧University of Surrey; University College London; University of Reading
- Philippa J. Talmud🇬🇧University of Surrey; University College London; University of Reading
- John W. Wright🇬🇧University of Surrey; University College London; University of Reading
- Margaret C. Murphy🇬🇧University of Surrey; University College London; University of Reading
- Bruce Arthur Griffin🇬🇧University of Surrey; University College London; University of Reading
- Christine M. Williams🇬🇧University of Surrey; University College London; University of Reading
Resumen
El texto original del estudio, en el idioma en que se publicó.
The study assessed the efficacy of fish oil supplementation in counteracting the classic dyslipidemia of the atherogenic lipoprotein phenotype (ALP). In addition, the impact of the common apolipoprotein E (apoE) polymorphism on the fasting and postprandial lipid profile and on responsiveness to the dietary intervention was established. Fifty-five ALP males (aged 34 to 69 years, body mass index 22 to 35 kg/m(2), triglyceride [TG] levels 1.5 to 4.0 mmol/L, high density lipoprotein cholesterol [HDL-C] 40% total LDL) completed a randomized placebo-controlled crossover trial of fish oil (3.0 g eicosapentaenoic acid/docosahexaenoic acid per day) and placebo (olive oil) capsules with the 6-week treatment arms separated by a 12-week washout period. In addition to fasting blood samples, at the end of each intervention arm, a postprandial assessment of lipid metabolism was carried out. Fish oil supplementation resulted in a reduction in fasting TG level of 35% (P<0.001), in postprandial TG response of 26% (TG area under the curve, P<0.001), and in percent LDL-3 of 26% (P<0.05). However, no change in HDL-C levels was evident (P=0.752). ANCOVA showed that baseline HDL-C levels were significantly lower in apoE4 carriers (P=0.035). The apoE genotype also had a striking impact on lipid responses to fish oil intervention. Individuals with an apoE2 allele displayed a marked reduction in postprandial incremental TG response (TG incremental area under the curve, P=0.023) and a trend toward an increase in lipoprotein lipase activity relative to non-E2 carriers. In apoE4 individuals, a significant increase in total cholesterol and a trend toward a reduction in HDL-C relative to the common homozygous E3/E3 profile was evident. Our data demonstrate the efficacy of fish oil fatty acids in counteracting the proatherogenic lipid profile of the ALP but also that the apoE genotype influences responsiveness to this dietary treatment.
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