Dietary creatine supplementation does not affect some haematological indices, or indices of muscle damage and hepatic and renal function
Robinson TM, Sewell DA, Casey A, Steenge G, Greenhaff PL
British journal of sports medicine · 54 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2000-08-01 · Br J Sports Med · vol. 34 · número 4 · págs. 284–288
- Editorial
- BMJ
- Citado
- 115 citas · más que el 89% de estudios similares · 2.7× el promedio de su campo
- Referencias
- 19 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Muscle metabolism and nutrition · Biochemical effects in animals · Exercise and Physiological Responses
- Palabras clave
- creatine supplementation, dietary creatine, hematological parameters, muscle damage, liver function, renal function, serum creatinine, creatine kinase, health risks of supplements, athletes
- MeSH
- muscle, skeletal, liver, kidney, blood, humans, creatine, blood chemical analysis, dietary supplements, adult, female, male
5 autores
- Tristan M. Robinson🇬🇧University of Nottingham; Queen's Medical Centre
- Dean A. Sewell🇬🇧University of Nottingham; Queen's Medical Centre
- A. E. Casey🇬🇧University of Nottingham; Queen's Medical Centre
- Gery R. Steenge🇬🇧University of Nottingham; Queen's Medical Centre
- Paul Leonard Greenhaff🇬🇧 · autor de correspondenciaUniversity of Nottingham; Queen's Medical Centre
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The use of creatine (Cr) as a nutritional supplement to aid athletic performance has gained widespread popularity among athletes. However, concerns have recently been expressed over potentially harmful effects of short and long term Cr supplementation on health.
Methods
Forty eight young healthy subjects were randomly allocated to three experimental protocols aimed at elucidating any potential health risks associated with five days (20 g/day) to nine weeks (3 g/day) of Cr supplementation. Venous blood samples were collected before and after periods of Cr supplementation and were analysed for some haematological indices, and for indices of hepatic, muscular, and renal dysfunction.
Findings
All measured indices were well within their respective normal range at all times. Serum creatinine concentration tended to be increased the day after Cr supplementation. However, values had returned to baseline six weeks after the cessation of supplementation. These increases were probably attributable to increased creatinine production rather than renal dysfunction. No indication of impairment to the haematological indices measured, hepatic function, or muscle damage was apparent after Cr supplementation.
Interpretation
These data provide evidence that there are no obvious adverse effects of acute or more chronic Cr supplementation on the haematological indices measured, nor on hepatic, muscle, and renal function. Therefore there is no apparent health risk associated with Cr supplementation to healthy people when it is ingested in quantities that have been scientifically proven to increase muscle Cr stores.
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