Supplementation of postmenopausal women with fish oil rich in eicosapentaenoic acid and docosahexaenoic acid is not associated with greater in vivo lipid peroxidation compared with oils rich in oleate and linoleate as assessed by plasma malondialdehyde and F(2)-isoprostanes
Higdon JV, Liu J, Du SH, Morrow JD, Ames BN, Wander RC
The American journal of clinical nutrition · 90 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute of General Medical Sciences
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- NIDDK NIH HHS
- Gobierno
- NIGMS NIH HHS
- Subvenciones
- National Institute of General Medical Sciences (GM 42056); National Institute of Diabetes and Digestive and Kidney Diseases (DK 48831); National Institute of General Medical Sciences (GM1543)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2000-09-01 · Am J Clin Nutr · vol. 72 · número 3 · págs. 714–722
- Editorial
- Elsevier BV
- Citado
- 124 citas · más que el 98% de estudios similares · 7.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 52 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Antioxidant Activity and Oxidative Stress · Edible Oils Quality and Analysis
- Palabras clave
- fish oil supplementation, eicosapentaenoic acid, docosahexaenoic acid, lipid peroxidation, postmenopausal women, F2-isoprostanes, malondialdehyde, TBARS, sunflower oil, safflower oil, oleate, linoleate, polyunsaturated fatty acids, arachidonic acid
- MeSH
- humans, malondialdehyde, lipid peroxides, vitamin e, docosahexaenoic acids, eicosapentaenoic acid, fatty acids, dinoprost, linoleic acid, oleic acid, fish oils, diet, postmenopause, dietary supplements, aged, middle aged
6 autores
- Jane V. Higdon🇺🇸Oregon State University; Vanderbilt University; University of California, Berkeley
- Jiankang Liu🇺🇸Oregon State University; Vanderbilt University; University of California, Berkeley
- Shi-Hua Du🇺🇸Oregon State University; Vanderbilt University; University of California, Berkeley
- Jason D. Morrow🇺🇸Oregon State University; Vanderbilt University; University of California, Berkeley
- Bruce N. Ames🇺🇸Oregon State University; Vanderbilt University; University of California, Berkeley
- Rosemary C. Wander🇺🇸 · autor de correspondenciaOregon State University; Vanderbilt University; University of California, Berkeley
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Although the replacement of dietary saturated fat with unsaturated fat has been advocated to reduce the risk of cardiovascular disease, diets high in polyunsaturated fatty acids (PUFAs) could increase lipid peroxidation, potentially contributing to the pathology of atherosclerosis.
Objective
The objective of this study was to examine indexes of in vivo lipid peroxidation, including free F(2)-isoprostanes, malondialdehyde (MDA), and thiobarbituric acid reacting substances (TBARS), in the plasma of postmenopausal women taking dietary oil supplements rich in oleate, linoleate, and both eicosapentaenoic acid and docosahexaenoic acid.
Design
Fifteen postmenopausal women took 15 g sunflower oil/d, providing 12.3 g oleate/d; safflower oil, providing 10.5 g linoleate/d; and fish oil, providing 2.0 g EPA/d and 1.4 g DHA/d in a 3-treatment crossover trial.
Results
Plasma free F(2)-isoprostane concentrations were lower after fish-oil supplementation than after sunflower-oil supplementation (P: = 0.003). When plasma free F(2)-isoprostane concentrations were normalized to plasma arachidonic acid concentrations, significant differences among the supplements were eliminated. Plasma MDA concentrations were lower after fish-oil supplementation than after sunflower-oil supplementation (P: = 0.04), whereas plasma TBARS were higher after fish-oil supplementation than after sunflower oil (P: = 0.003) and safflower oil (P: = 0.001) supplementation. When plasma MDA concentrations were normalized to plasma PUFA concentrations, significant differences were eliminated, but TBARS remained higher after fish-oil supplementation than after sunflower oil (P: = 0.01) and safflower-oil (P: = 0.0003) supplementation.
Conclusions
With fish-oil supplementation, there was no evidence of increased lipid peroxidation when assessed by plasma F(2)-isoprostanes and MDA, although plasma TBARS was higher than with sunflower-oil and safflower-oil supplementation.
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