Lipoprotein(a) and coronary heart disease. Meta-analysis of prospective studies
Danesh J, Collins R, Peto R
Circulation · 562 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2000-09-05 · Circulation · vol. 102 · número 10 · págs. 1082–1085
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 938 citas · más que el 100% de estudios similares · 44.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 40 trabajos
- Acceso
- De pago
- Áreas de investigación
- Lipoproteins and Cardiovascular Health · Atherosclerosis and Cardiovascular Diseases · Paraoxonase enzyme and polymorphisms
- Palabras clave
- lipoprotein(a), coronary artery disease, cardiovascular risk factors, myocardial infarction, plasma Lp(a) concentration, prospective cohort, blood storage temperature, vascular risk factors
- MeSH
- humans, coronary disease, lipoprotein(a), risk factors, case-control studies, prospective studies, aged, middle aged, female, male
3 autores
- John Danesh🇬🇧University of Oxford
- Rory Collins🇬🇧University of Oxford
- Richard Peto🇬🇧University of Oxford
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
-Studies of the association between the plasma concentration of lipoprotein(a) [Lp(a)] and coronary heart disease (CHD) have reported apparently conflicting findings. We report a meta-analysis of the prospective studies with at least 1 year of follow-up published before 2000.
Methods and results
The following information was abstracted for each study: geographical location of study, size, type of cohort (population-based or selected because of previous disease), mean age, follow-up duration, blood storage temperature and duration, assay methods, degree of adjustment for potential confounders, and relationship of baseline Lp(a) measurement with subsequent CHD risk. There were 5436 deaths from CHD or nonfatal myocardial infarctions during a weighted mean follow-up of 10 years in the 27 eligible studies. Comparison of individuals in the top third of baseline plasma Lp(a) measurements with those in the bottom third in each study yielded a combined risk ratio of 1.6 (95% CI 1.4 to 1.8, 2P:<0.00001), with similar findings when the analyses were restricted to the 18 studies of general populations (combined risk ratio 1.7, 95% CI 1.4 to 1.9; 2P:<0. 00001). Despite differences among studies in blood storage techniques and assay methods, there was no significant heterogeneity among the results from the 18 population-based studies or among those from the 9 studies of patients with previous disease. Lp(a) was only weakly correlated with classical vascular risk factors, and adjustment for those that had been recorded made little difference to the reported risk ratios.
Conclusions
These prospective studies demonstrate a clear association between Lp(a) and CHD, but further studies are needed to determine the extent to which this is causal.
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