Docosahexaenoic acid transfer into human milk after dietary supplementation: a randomized clinical trial
Fidler N, Sauerwald T, Pohl A, Demmelmair H, Koletzko B
Journal of lipid research · 101 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Sin resultado de salud
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2000-09-01 · J Lipid Res · vol. 41 · número 9 · págs. 1376–1383
- Editorial
- Elsevier BV
- Citado
- 184 citas · más que el 95% de estudios similares · 4.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 42 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Fatty Acid Research and Health · Infant Nutrition and Health · Breastfeeding Practices and Influences
- Palabras clave
- docosahexaenoic acid, breast milk, dietary supplementation, fatty acid uptake, lactation, isotopic labeling, 13C-labeled fatty acids, milk fatty acid composition, palmitic acid, oleic acid, myristic acid, infant development
- MeSH
- milk, human, humans, carbon isotopes, dietary fats, docosahexaenoic acids, oleic acid, palmitic acid, placebos, lactation, dietary supplements, adult, female, gas chromatography-mass spectrometry
5 autores
- Nataša Fidler Mis🇩🇪Ludwig-Maximilians-Universität München
- Thorsten U. Sauerwald🇩🇪Ludwig-Maximilians-Universität München
- Anja Pohl🇩🇪Ludwig-Maximilians-Universität München
- Hans Demmelmair🇩🇪Ludwig-Maximilians-Universität München
- Berthold Viktor Koletzko🇩🇪 · autor de correspondenciaLudwig-Maximilians-Universität München
Resumen
El texto original del estudio, en el idioma en que se publicó.
Docosahexaenoic acid (DHA) is important for infant development. The DHA transfer from maternal diet into human milk has not been investigated in detail. We studied the effects of DHA supplementation on the fatty acid composition of human milk and the secretion of dietary (13)C-labeled fatty acids, including DHA, into human milk. Ten lactating women were randomized to consume, from 4 to 6 weeks postpartum, an oil rich in DHA (DHASCO, 200 mg of DHA/day) (n = 5) or a placebo oil (n = 5). Dietary intakes were followed by 7-day protocols. On study day 14 a single dose of [U-(13)C]DHASCO was given orally, milk samples were collected over 48 h, and milk production was recorded. Milk fatty acid composition was determined by gas-liquid chromatography and isotopic enrichment was determined by gas chromatography- combustion-isotope ratio mass spectrometry (GC-C-IRMS). Milk DHA content did not differ between the supplemented and placebo group at study entry (0.29 vs. 0.28 wt%, median). After 2 weeks of supplementation the milk DHA content was almost 2-fold higher in the supplemented versus placebo group (0.37 vs. 0.21 wt%, P = 0.003). Cumulative recovery of [(13)C]palmitic, [(13)C]oleic, and [(13)C]docosahexaenoic acids in human milk at 48 h was similar between supplemented and placebo groups (palmitic acid 7.40 vs. 8. 14%, oleic acid 9.14 vs. 9.97%, and docosahexaenoic acid 9.09 vs. 8. 03% of dose, respectively). Notable lower recovery was observed for [(13)C]myristic acid in both the supplemented and placebo groups, 0. 62 versus 0.77% of dose. Dietary DHA supplementation increases the DHA content in human milk. DHA transfer from the diet into human milk is comparable to palmitic and oleic acid transfer.
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