Differential effects of eicosapentaenoic acid and docosahexaenoic acid on vascular reactivity of the forearm microcirculation in hyperlipidemic, overweight men
Mori TA, Watts GF, Burke V, Hilme E, Puddey IB, Beilin LJ
Circulation · 240 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2000-09-12 · Circulation · vol. 102 · número 11 · págs. 1264–1269
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 360 citas · más que el 98% de estudios similares · 9.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 40 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Eicosanoids and Hypertension Pharmacology · Nitric Oxide and Endothelin Effects
- Palabras clave
- eicosapentaenoic acid, docosahexaenoic acid, omega-3 fatty acids, fish oil supplementation, forearm blood flow, vascular reactivity, hyperlipidemia, overweight men, acetylcholine, nitric oxide, L-NMMA, norepinephrine, sodium nitroprusside, vasodilation, vasoconstriction
- MeSH
- forearm, muscle, smooth, vascular, microcirculation, humans, obesity, nitroprusside, norepinephrine, acetylcholine, insulin, blood glucose, lipids, docosahexaenoic acids, eicosapentaenoic acid, lipoproteins, ldl, omega-n-methylarginine, adrenergic alpha-agonists, nitric oxide donors, vasoconstrictor agents, vasodilator agents, plethysmography, double-blind method, vasoconstriction, vasodilation, particle size, adult, aged, middle aged, male, hyperlipidemias
6 autores
- Trevor Anthony Mori🇦🇺The University of Western Australia
- Gerald F. Watts🇦🇺The University of Western Australia
- Valerie Burke🇦🇺The University of Western Australia
- Elisabet Hilme🇦🇺The University of Western Australia
- Ian B. Puddey🇦🇺The University of Western Australia
- Lawrence Joseph Beilin🇦🇺The University of Western Australia
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Recent evidence supports differential effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), the 2 major omega3 fatty acids of marine origin, on blood pressure in humans and vascular reactivity in adult spontaneously hypertensive rats. We investigated possible differences in the effects of purified EPA or DHA on forearm vascular reactivity in overweight hyperlipidemic men that might contribute to the blood pressure-lowering effects of fish oils.
Methods and results
With a double-blind, placebo-controlled trial of parallel design, 59 overweight, mildly hyperlipidemic men were randomized to receive 4 g/d purified EPA, DHA, or olive oil (placebo) capsules while continuing their usual diets for 6 weeks. Forearm blood flow (FBF) was measured with venous occlusion, strain-gauge plethysmography during the sequential intra-arterial administration of acetylcholine (7.5, 15, and 30 microg/min), sodium nitroprusside (1.5, 3, and 10 microg/min), norepinephrine (10, 20, and 40 ng/min), a single-dose infusion of N:(G)-monomethyl-L-arginine (L-NMMA) (1 mg/min), and coinfusion of acetylcholine (7.5, 15, and 30 microg/min) and L-NMMA. Forty of the 56 subjects who completed the study underwent FBF measurements. Plasma phospholipid EPA levels increased significantly (P:<0.0001) after supplementation with EPA, and DHA composition increased with DHA supplementation (P:<0.0001). Relative to placebo, DHA, but not EPA, supplementation significantly improved FBF in response to acetylcholine infusion (P:=0.040) and coinfusion of acetylcholine with L-NMMA (P:=0.040). Infusion of L-NMMA alone showed no group differences. DHA significantly enhanced dilatory responses to sodium nitroprusside (P:<0.0001) and attenuated constrictor responses to norepinephrine (P:=0.017).
Conclusions
Relative to placebo, DHA, but not EPA, enhances vasodilator mechanisms and attenuates constrictor responses in the forearm microcirculation. Improvements in endothelium-independent mechanisms appear to be predominant and may contribute to the selective blood pressure-lowering effect observed with DHA compared with EPA in humans.
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