Dietary unsaturated fatty acids in type 2 diabetes: higher levels of postprandial lipoprotein on a linoleic acid-rich sunflower oil diet compared with an oleic acid-rich olive oil diet
Madigan C, Ryan M, Owens D, Collins P, Tomkin GH
Diabetes care · 47 citas
Etiquetas de revisión
Alimentación controladaFinanciación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2000-10-01 · Diabetes Care · vol. 23 · número 10 · págs. 1472–1477
- Editorial
- American Diabetes Association
- Citado
- 89 citas · más que el 93% de estudios similares · 3.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 0 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Nutritional Studies and Diet · Lipoproteins and Cardiovascular Health
- Palabras clave
- type 2 diabetes, linoleic acid, oleic acid, sunflower oil, olive oil, polyunsaturated fatty acids, monounsaturated fatty acids, postprandial lipoproteins, chylomicron remnants, apolipoprotein B-48, apolipoprotein B-100, VLDL, LDL cholesterol, serum cholesterol, fasting insulin, atherosclerosis risk
- MeSH
- humans, arteriosclerosis, diabetes mellitus, type 2, cholesterol, blood glucose, dietary fats, unsaturated, oleic acid, triglycerides, lipoproteins, plant oils, apolipoproteins b, cross-over studies, energy intake, postprandial period, middle aged, male, cholesterol, ldl, cholesterol, hdl, apolipoprotein b-48, olive oil
5 autores
- C Madigan🇨🇦🇮🇪Trinity College; Trinity College Dublin
- M Ryan🇨🇦🇮🇪Trinity College; Trinity College Dublin
- D Owens🇨🇦🇮🇪Trinity College; Trinity College Dublin
- Peter M. Collins🇨🇦🇮🇪Trinity College; Trinity College Dublin
- G.H. Tomkin🇨🇦🇮🇪Trinity College; Trinity College Dublin
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
The present study was undertaken to examine the effect of a polyunsaturated fat diet compared with an isocaloric Mediterranean-style monounsaturated fat diet.
Research design and methods
This was a randomized 2-week crossover study on either a high-polyunsaturated or a high-monounsaturated fat diet in 11 well-controlled diabetic men. Blood was taken fasting and for up to 8 h after a high fat meal. Lipoproteins were isolated by sequential ultracentrifugation. Apolipoprotein (apo) B48 and apo B100 were separated by PAGE. Fatty acids were analyzed by gas-liquid chromatography
Results
Fasting blood glucose and insulin levels were significantly higher on the linoleic acid diet compared with the oleic acid diet (P < 0.01 and P < 0.002, respectively). Plasma cholesterol and LDL cholesterol levels were also significantly higher on the linoleic acid diet (P < 0.001). Likewise, fasting chylomicron apo B48 and apo B100 (P < 0.05) and postprandial chylomicron and VLDL apo B48 and B100 (P < 0.05) were also higher on the linoleic acid diet.
Conclusions
This study suggests that, in type 2 diabetes, an oleic acid-rich Mediterranean-type diet versus a linoleic acid-enriched diet may reduce the risk of atherosclerosis by decreasing the number of chylomicron remnant particles.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.