Caffeine potentiates low frequency skeletal muscle force in habitual and nonhabitual caffeine consumers
Tarnopolsky M, Cupido C
Journal of applied physiology (Bethesda, Md. : 1985) · 124 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2000-11-01 · J Appl Physiol (1985) · vol. 89 · número 5 · págs. 1719–1724
- Editorial
- American Physiological Society
- Citado
- 206 citas · más que el 84% de estudios similares · 1.7× el promedio de su campo
- Referencias
- 39 trabajos
- Acceso
- De pago
- Áreas de investigación
- Coffee research and impacts · Muscle metabolism and nutrition · Sports Performance and Training
- Palabras clave
- caffeine, ergogenic aids, skeletal muscle contraction, low-frequency stimulation, calcium release, sarcoplasmic reticulum, endurance exercise performance, peroneal nerve stimulation
- MeSH
- muscle, skeletal, humans, substance-related disorders, caffeine, central nervous system stimulants, cross-over studies, double-blind method, electric stimulation, volition, muscle fatigue, physical endurance, muscle contraction, torque, adult, male
2 autores
- Mark Andrew Tarnopolsky🇨🇦McMaster University Medical Centre; McMaster University
- Cynthia M. Cupido🇨🇦McMaster University Medical Centre; McMaster University
Resumen
El texto original del estudio, en el idioma en que se publicó.
The mechanism of action underlying the ergogenic effect of caffeine is still unclear. Caffeine increases the force of muscular contraction during low-frequency stimulation by potentiating calcium release from the sarcoplasmic reticulum. Studies have also suggested an enhancement of lipid oxidation and glycogen sparing as potential mechanisms. Given that several studies have found an ergogenic effect of caffeine with no apparent metabolic effects, it is likely that a direct effect upon muscle is important. Twelve healthy male subjects were classified as habitual (n = 6) or nonhabitual (n = 6) caffeine consumers based on a 4-day diet record analysis, with a mean caffeine consumption of 771 and 14 mg/day for each group, respectively. Subjects were randomly allocated to receive caffeine (6 mg/kg) and placebo (citrate) in a double-blind, cross-over fashion approximately 100 min before a 2-min tetanic stimulation of the common peroneal nerve in a custom-made dynamometer (2 trials each of 20 and 40 Hz). Tetanic torque was measured every 30 s during and at 1, 5, and 15 min after the stimulation protocol. Maximal voluntary contraction strength and peak twitch torque were measured before and after the stimulation protocol. Caffeine potentiated the force of contraction during the final minute of the 20-Hz stimulation (P<0.05) with no effect of habituation. There was no effect of caffeine on 40-Hz stimulation strength nor was there an effect on maximal voluntary contraction or peak twitch torque. These data support the hypothesis that some of the ergogenic effect of caffeine in endurance exercise performance occurs directly at the skeletal muscle level.
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