Oral magnesium therapy improves endothelial function in patients with coronary artery disease
Shechter M, Sharir M, Labrador MJ, Forrester J, Silver B, Bairey Merz CN
Circulation · 176 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Cedars-Sinai Medical Center
Según 1 financiador declarado.
Publicación
- Publicado
- 2000-11-07 · Circulation · vol. 102 · número 19 · págs. 2353–2358
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 298 citas · más que el 98% de estudios similares · 8.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 37 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Magnesium in Health and Disease · Cardiovascular Health and Disease Prevention · Nitric Oxide and Endothelin Effects
- Palabras clave
- oral magnesium supplementation, coronary artery disease, endothelial function, flow-mediated dilation, intracellular magnesium, exercise tolerance, exercise stress testing, ST-segment changes, brachial artery
- MeSH
- brachial artery, endothelium, vascular, humans, coronary disease, magnesium, placebos, treatment outcome, administration, oral, double-blind method, vasodilation, exercise tolerance, adult, aged, middle aged, female, male
6 autores
- Michael Shechter🇺🇸Cedars-Sinai Medical Center; University of California, Los Angeles
- Michael Sharir🇺🇸Cedars-Sinai Medical Center; University of California, Los Angeles
- Maura J. Paul-Labrador🇺🇸Cedars-Sinai Medical Center; University of California, Los Angeles
- James S. Forrester🇺🇸Cedars-Sinai Medical Center; University of California, Los Angeles
- Burton B. Silver🇺🇸Cedars-Sinai Medical Center; University of California, Los Angeles
- C. Noel Bairey Merz🇺🇸Cedars-Sinai Medical Center; University of California, Los Angeles
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Magnesium blocks many of the physiological actions of calcium. Nevertheless, the impact of magnesium supplementation on endothelial function and exercise tolerance in stable coronary artery disease (CAD) patients has not been assessed.
Methods and results
In a randomized, double-blind, placebo-controlled trial, 50 stable CAD patients (41 men and 9 women, mean+/-SD age 67+/-11 years, age range 42 to 82 years) were randomized to receive either magnesium (n=25) (30 mmol/d Magnosolv-Granulat; Asta Medica Company, Inc) or placebo (n=25) for 6 months. Before and after 6 months, endothelium-dependent brachial artery flow-mediated vasodilation (FMD) and endothelium-independent NTG-mediated vasodilation were assessed with high-resolution (10-MHz) ultrasound. Exercise stress testing was performed with use of the Bruce protocol. Intracellular magnesium concentrations ([Mg(2+)](i)) were assessed from sublingual cells through x-ray dispersion (EXA) (normal mean+/-SD values 37. 9+/-4.0 mEq/L). The magnesium therapy significantly increased postintervention ([Mg(2+)](i) versus placebo (36.2+/-5.0 versus 32.7+/-2.7 mEq/L, P<0.02). There was a significant correlation in the total population between baseline [Mg(2+)](i) and baseline FMD (r=0. 48, P<0.01). The magnesium intervention resulted in a significant improvement in postintervention FMD (15.5+/-12.0%, P=0.02 compared with baseline), which was not evident with placebo (4.4+/-2.5%, P=0.78 compared with baseline). There was better exercise tolerance (9.3+/-2.0 versus 7.3+/-3.1 minutes, P=0.05) and less ischemic ST-segment changes (4 versus 10 patients, P=0.05) in the magnesium versus placebo groups, respectively.
Conclusions
Oral magnesium therapy in CAD patients is associated with significant improvement in brachial artery endothelial function and exercise tolerance, suggesting a potential mechanism by which magnesium could beneficially alter outcomes in CAD patients.
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