Influence of age and dietary fish oil on plasma soluble adhesion molecule concentrations
Miles EA, Thies F, Wallace FA, Powell JR, Hurst TL, Newsholme EA, Calder PC
Clinical science (London, England : 1979) · 83 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2000-12-13 · Clin Sci (Lond) · vol. 100 · número 1 · págs. 91–100
- Editorial
- Portland Press
- Citado
- 129 citas · más que el 93% de estudios similares · 3.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 0 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Cell Adhesion Molecules Research · Adipokines, Inflammation, and Metabolic Diseases
- Palabras clave
- soluble adhesion molecules, ICAM-1, VCAM-1, E-selectin, fish oil supplementation, eicosapentaenoic acid, plasma phospholipids, aging, age differences, older men, inflammation, endothelial adhesion molecules, sex differences, dietary fatty acids, healthy adults, body mass index, cholesterol, triglycerides
- MeSH
- humans, thiobarbituric acid reactive substances, dietary fats, unsaturated, eicosapentaenoic acid, fish oils, cell adhesion molecules, intercellular adhesion molecule-1, e-selectin, vascular cell adhesion molecule-1, double-blind method, aging, solubility, adult, aged, middle aged, female, male
7 autores
- Elizabeth A. Miles🇬🇧University of Southampton
- Frank Thiès🇬🇧University of Oxford
- Fiona A. WALLACE🇬🇧University of Southampton
- Jonathan R. Powell🇬🇧Unilever (United Kingdom)
- TINA L. HURST🇬🇧Unilever (United Kingdom)
- Eric A. NEWSHOLME🇬🇧University of Oxford
- Philip C. Calder🇬🇧University of Southampton
Resumen
El texto original del estudio, en el idioma en que se publicó.
Soluble forms of intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and E-selectin (termed sICAM-1, sVCAM-1 and sE-selectin respectively) are found in the plasma, and are elevated during inflammatory conditions in which there is increased expression of the cellular forms of the molecules on endothelial and other cells. sICAM-1, sVCAM-1 and sE-selectin concentrations were measured in the plasma of 140 healthy Caucasian subjects aged between 18 and 75 years (100 males/40 females). sICAM-1 concentrations varied between 59.9 and 299.7 ng/ml (median 150 ng/ml), sVCAM-1 concentrations varied between 222.8 and 1672.9 ng/ml (median 662 ng/ml) and sE-selectin concentrations varied between 12.4 and 90.3 ng/ml (median 45.5 ng/ml). There were significant positive linear correlations between age and the plasma concentrations of sICAM-1 (r=0.580; P55 years of age (both P55 years of age) participated in a doubled-blind, placebo-controlled study of fish oil supplementation over 12 weeks. The level of eicosapentaenoic acid in plasma phospholipids did not change with placebo supplementation, but was significantly increased with fish oil supplementation in both young male and elderly subjects (median increase 200%). sICAM-1, sVCAM-1 and sE-selectin concentrations were unaffected by supplementation with placebo in either young male or elderly subjects. sICAM-1 concentrations were unaffected by fish oil supplementation. sE-selectin concentrations were significantly increased by fish oil supplementation in young males (P=0.043; median increase 38%), but fish oil tended to decrease plasma sE-selectin concentrations in the elderly subjects (P=0.075), with a median decrease of 11%. sVCAM-1 concentrations were unaffected by fish oil supplementation in young males. Fish oil supplementation significantly decreased plasma sVCAM-1 concentrations in the elderly subjects (P=0.043), with a median decrease of 20% (range 16-60%). These observations suggest that fish oil decreases endothelial activation in elderly subjects.
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