High-monounsaturated fat, olive oil-rich diet has effects similar to a high-carbohydrate diet on fasting and postprandial state and metabolic profiles of patients with type 2 diabetes
Rodríguez-Villar C, Manzanares JM, Casals E, Pérez-Heras A, Zambón D, Gomis R, Ros E
Metabolism: clinical and experimental · 23 citas
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Cómo se estudió
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- Ensayo controlado aleatorizado (indexado por PubMed)
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- Resultado principal
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Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2000-12-01 · Metabolism · vol. 49 · número 12 · págs. 1511–1517
- Editorial
- Elsevier BV
- Citado
- 37 citas · más que el 58% de estudios similares · 0.2× el promedio de su campo
- Referencias
- 51 trabajos
- Acceso
- De pago
- Áreas de investigación
- Diet and metabolism studies · Nutritional Studies and Diet · Diet, Metabolism, and Disease
- Palabras clave
- type 2 diabetes, olive oil, high-fat diet, low-fat diet, postprandial hypertriglyceridemia, triglyceride-rich lipoproteins, postprandial blood glucose, insulin, lipoproteins, dietary fat composition, atherogenic risk
- MeSH
- humans, diabetes mellitus, type 2, dietary carbohydrates, dietary fats, unsaturated, triglycerides, plant oils, diet, fasting, postprandial period, olive oil
7 autores
- Camino Rodrı́guez-Villar🇪🇸Hospital Clínic de Barcelona; Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
- José María Manzanares🇪🇸Hospital Clínic de Barcelona; Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
- Elena Casals🇪🇸Hospital Clínic de Barcelona; Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
- Ana Pérez-Heras🇪🇸Hospital Clínic de Barcelona; Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
- Daniel Zambón🇪🇸Hospital Clínic de Barcelona; Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
- Ramón Gomis🇪🇸Hospital Clínic de Barcelona; Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
- Emilio Ros🇪🇸Hospital Clínic de Barcelona; Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
Resumen
El texto original del estudio, en el idioma en que se publicó.
Whether metabolic control in type 2 diabetes mellitus (DM) is best achieved with the traditional high-carbohydrate (CHO), low-fat diet or a low-CHO, high-fat diet is still controversial. In a randomized crossover study, we compared the effects of a low-fat (30% of daily energy) diet and a high-fat (40% of daily energy), high-monounsaturated-fat diet for 6 weeks each on fasting and postprandial glucose, insulin, and lipoprotein concentrations in 12 patients with well-controlled type 2 DM (fasting blood glucose, 176 +/- 54 mg/dL; hemoglobin A1c, 6.4% +/- 0.7%) and no overt dyslipidemia (serum total cholesterol, 235 +/- 43 mg/dL; triglycerides, 180 +/- 63 mg/dL). Home-prepared foods were used and olive oil was the main edible fat, accounting for 8% and 25% of daily energy requirements in the low-fat and high-fat diets, respectively. For postprandial studies, the same mixed meal containing 36% fat was used in both dietary periods. Body weight and fasting and 6-hour postprandial blood glucose, insulin, and lipoprotein levels were similar after the two diets. The mean incremental area under the curve of serum triglycerides 0 to 6 hours after the challenge meal, adjusted for baseline levels, did not change significantly after the high-fat diet compared with the low-fat diet (1,484 +/- 546 v 1,714 +/- 709 mg x 6 h/dL, respectively, P = .099). Mean postprandial triglyceride levels at 6 hours were increased about 2 times over fasting levels and were still greater than 300 mg/dL after either diet. A diet high in total and monounsaturated fat at the expense of olive oil is a good alternative diet to the traditional low-fat diet for patients with type 2 DM. However, ongoing postprandial hypertriglyceridemia with either diet points to the need for other therapies to decrease triglyceride-rich lipoproteins (TRL) and the inherent atherogenic risk in type 2 diabetics.
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