Effect of oral creatine supplementation on human muscle GLUT4 protein content after immobilization
Op 't Eijnde B, Ursø B, Richter EA, Greenhaff PL, Hespel P
Diabetes · 92 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
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Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2001-01-01 · Diabetes · vol. 50 · número 1 · págs. 18–23
- Editorial
- American Diabetes Association
- Citado
- 161 citas · más que el 91% de estudios similares · 3.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 45 trabajos
- Acceso
- De pago
- Áreas de investigación
- Muscle metabolism and nutrition · Muscle Physiology and Disorders · Exercise and Physiological Responses
- Palabras clave
- creatine monohydrate supplementation, muscle disuse, immobilization, resistance training, muscle glycogen, muscle creatine, vastus lateralis, rehabilitation training, skeletal muscle glucose transport
- MeSH
- leg, muscle, skeletal, humans, muscular atrophy, creatine, glycogen, monosaccharide transport proteins, muscle proteins, administration, oral, double-blind method, immobilization, casts, surgical, physical education and training, weight lifting, adult, female, male, glucose transporter type 4
5 autores
- Bert O. Eijnde🇩🇰🇬🇧🇧🇪University of Copenhagen; University of Nottingham; Queen's Medical Centre; Copenhagen Muscle Research Centre; KU Leuven
- Birgitte Ursø🇩🇰🇬🇧🇧🇪University of Copenhagen; University of Nottingham; Queen's Medical Centre; Copenhagen Muscle Research Centre; KU Leuven
- Erik Arne Richter🇩🇰🇬🇧🇧🇪University of Copenhagen; University of Nottingham; Queen's Medical Centre; Copenhagen Muscle Research Centre; KU Leuven
- Paul Leonard Greenhaff🇩🇰🇬🇧🇧🇪University of Copenhagen; University of Nottingham; Queen's Medical Centre; Copenhagen Muscle Research Centre; KU Leuven
- Peter Hespel🇩🇰🇬🇧🇧🇪University of Copenhagen; University of Nottingham; Queen's Medical Centre; Copenhagen Muscle Research Centre; KU Leuven
Resumen
El texto original del estudio, en el idioma en que se publicó.
The purpose of this study was to investigate the effect of oral creatine supplementation on muscle GLUT4 protein content and total creatine and glycogen content during muscle disuse and subsequent training. A double-blind placebo-controlled trial was performed with 22 young healthy volunteers. The right leg of each subject was immobilized using a cast for 2 weeks, after which subjects participated in a 10-week heavy resistance training program involving the knee-extensor muscles (three sessions per week). Half of the subjects received creatine monohydrate supplements (20 g daily during the immobilization period and 15 and 5 g daily during the first 3 and the last 7 weeks of rehabilitation training, respectively), whereas the other 11 subjects ingested placebo (maltodextrine). Muscle GLUT4 protein content and glycogen and total creatine concentrations were assayed in needle biopsy samples from the vastus lateralis muscle before and after immobilization and after 3 and 10 weeks of training. Immobilization decreased GLUT4 in the placebo group (-20%, P < 0.05), but not in the creatine group (+9% NS). Glycogen and total creatine were unchanged in both groups during the immobilization period. In the placebo group, during training, GLUT4 was normalized, and glycogen and total creatine were stable. Conversely, in the creatine group, GLUT4 increased by approximately 40% (P < 0.05) during rehabilitation. Muscle glycogen and total creatine levels were higher in the creatine group after 3 weeks of rehabilitation (P < 0.05), but not after 10 weeks of rehabilitation. We concluded that 1) oral creatine supplementation offsets the decline in muscle GLUT4 protein content that occurs during immobilization, and 2) oral creatine supplementation increases GLUT4 protein content during subsequent rehabilitation training in healthy subjects.
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