Effect of three caffeine doses on plasma catecholamines and alertness during prolonged wakefulness
Kamimori GH, Penetar DM, Headley DB, Thorne DR, Otterstetter R, Belenky G
European journal of clinical pharmacology · 44 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2000-08-03 · Eur J Clin Pharmacol · vol. 56 · número 8 · págs. 537–544
- Editorial
- Springer Science+Business Media
- Citado
- 77 citas · más que el 97% de estudios similares · 7.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 0 trabajos
- Acceso
- De pago
- Áreas de investigación
- Sleep and Work-Related Fatigue · Coffee research and impacts · Sleep and Wakefulness Research
- Palabras clave
- caffeine, catecholamines, alertness, prolonged wakefulness, epinephrine, norepinephrine, sleepiness, reaction time, sleep latency, dose-response relationship, caffeine dose
- MeSH
- humans, sleep deprivation, epinephrine, norepinephrine, caffeine, central nervous system stimulants, double-blind method, wakefulness, reaction time, dose-response relationship, drug, adolescent, adult, male
6 autores
- Gary H. Kamimori🇺🇸Walter Reed Army Institute of Research
- David M. Penetar🇺🇸U.S. Army Research Institute of Environmental Medicine; United States Army
- Don B. Headley🇺🇸Walter Reed Army Institute of Research
- David R. Thorne🇺🇸Walter Reed Army Institute of Research
- Ronald Otterstetter🇺🇸Walter Reed Army Institute of Research
- Gregory Lucas Belenky🇺🇸Walter Reed Army Institute of Research
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Determine the relationship between caffeine, catecholamines, and alertness during prolonged wakefulness.
Methods
Following 49 h of prolonged wakefulness, each of 50 healthy males (18-32 years) orally ingested either a placebo or one of three doses of caffeine, 2.1 (low), 4.3 (medium), or 8.6 mg kg-1 body weight (high), in a randomized double-blind design. Wakefulness continued for an additional 12 h during which venous blood samples were collected for catecholamine and caffeine analysis [determined using high-performance liquid chromatography (HPLC)]. A sleep latency test, the Stanford sleepiness scale, and a choice reaction time test were administered periodically during the post-dosing period and served as measures of alertness (physiological, subjective, and behavioral, respectively).
Results
Caffeine had no significant effect on noradrenaline, but adrenaline was significantly increased between 1 h and 4 h post-dosing in the high dose group compared with a placebo group. Following caffeine administration, responses to sleep latency, sleepiness scores, and reaction time scores showed dose-related changes that were exhibited by significant correlation coefficients.
Conclusion
The results indicate that high doses of caffeine have a significant and beneficial effect on alertness during prolonged wakefulness.
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