Dietary supplementation with fish oil rich in omega-3 polyunsaturated fatty acids in children with bronchial asthma
Nagakura T, Matsuda S, Shichijyo K, Sugimoto H, Hata K
The European respiratory journal · 135 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2000-11-01 · Eur Respir J · vol. 16 · número 5 · págs. 861–865
- Editorial
- European Respiratory Society
- Citado
- 240 citas · más que el 96% de estudios similares · 5.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 20 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Asthma and respiratory diseases · Edible Oils Quality and Analysis
- Palabras clave
- fish oil supplementation, omega-3 polyunsaturated fatty acids, asthma, children, eicosapentaenoic acid, docosahexaenoic acid, acetylcholine responsiveness, asthma symptom scores, anti-inflammatory activity, olive oil placebo
- MeSH
- humans, asthma, acetylcholine, docosahexaenoic acids, eicosapentaenoic acid, fish oils, plant oils, bronchial provocation tests, double-blind method, dietary supplements, child, female, male, olive oil
5 autores
- Toshikazu Nagakura🇯🇵Jikei University School of Medicine
- S Matsuda
- Kouzaburo Shichijyo
- H Sugimoto
- K Hata
Resumen
El texto original del estudio, en el idioma en que se publicó.
Omega-3 polyunsaturated fatty acids have anti-inflammatory effects in vitro, and high dietary levels are associated with a lower incidence of inflammatory diseases. However, only limited effects have been demonstrated in asthma. The effects of dietary supplementation with fish oil for 10 months in 29 children with bronchial asthma was investigated in a randomized controlled fashion. In order to minimize the effects of environmental inhaled allergens and diet, this study was performed in a long-term treatment hospital. Subjects received fish oil capsules containing 84 mg eicosapentaenoic acid (EPA) and 36 mg docosahexaenoic acid (DHA) or control capsules containing 300 mg olive oil. The daily dosages of EPA and DHA were 17.0-26.8 and 7.3-11.5 mg x kg body weight(-1), respectively. Asthma symptom scores decreased and responsiveness to acetylcholine decreased in the fish oil group but not in the control group. In addition, plasma EPA levels increased significantly only in the fish oil group (p<0.0088). No significant side-effects were observed. The present results suggest that dietary supplementation with fish oil rich in the omega-3 polyunsaturated fatty acids eicosapentaenoic acid and docosahexaenoic acid is beneficial for children with bronchial asthma in a strictly controlled environment in terms of inhalant allergens and diet.
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