Oral creatine supplementation decreases plasma markers of adenine nucleotide degradation during a 1-h cycle test
Bellinger BM, Bold A, Wilson GR, Noakes TD, Myburgh KH
Acta physiologica Scandinavica · 12 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2000-11-07 · Acta Physiol Scand · vol. 170 · número 3 · págs. 217–224
- Editorial
- Wiley
- Citado
- 21 citas · más que el 60% de estudios similares · 0.4× el promedio de su campo
- Referencias
- 41 trabajos
- Acceso
- De pago
- Áreas de investigación
- Muscle metabolism and nutrition · Sports Performance and Training · Biochemical effects in animals
- Palabras clave
- creatine supplementation, adenine nucleotide degradation, blood ammonia, submaximal exercise, endurance cyclists, exercise performance, lactate
- MeSH
- muscle, skeletal, humans, ammonia, lactic acid, creatinine, hypoxanthine, uric acid, adenine nucleotides, exercise test, exercise, chromatography, high pressure liquid, double-blind method, dietary supplements, male
5 autores
- Brett Bellinger🇿🇦University of Cape Town
- A. Bold🇿🇦University of Cape Town
- Gregory Wilson🇿🇦University of Cape Town
- Timothy David Noakes🇿🇦University of Cape Town
- Kathryn Helen Myburgh🇿🇦University of Cape Town
Resumen
El texto original del estudio, en el idioma en que se publicó.
We investigated the effect of oral creatine supplementation (20 g d(-1) for 7 days) on metabolism during a 1-h cycling performance trial. Twenty endurance-trained cyclists participated in this double-blind placebo controlled study. Five days after familiarization with the exercise test, the subjects underwent a baseline muscle biopsy. Thereafter, a cannula was inserted into a forearm vein before performing the baseline maximal 1-h cycle (test 1 (T1)). Blood samples were drawn at regular intervals during exercise and recovery. After creatine (Cr) loading, the muscle biopsy, 1-h cycling test (test 2 (T2)) and blood sampling were repeated. Resting muscle total creatine (TCr), measured by high performance liquid chromatography, was increased (P < 0.001) in the creatine group from 123.0 +/- 3.8 - 159.8 +/- 7.9 mmol kg(-1) dry wt, but was unchanged in the placebo group (126.7 +/- 4.7 - 127.5 +/- 3.6 mmol kg(-1) dry wt). The extent of Cr loading was unrelated to baseline Cr levels (r=0.33, not significant). Supplementation did not significantly improve exercise performance (Cr group: 39.1 +/- 0.9 vs. 39.8 +/- 0.8 km and placebo group: 39.3 +/- 0.8 vs. 39.2 +/- 1.1 km) or change plasma lactate concentrations. Plasma concentrations of ammonia (NH(3)) (P < 0.05) and hypoxanthine (Hx) (P < 0.01) were lower in the Cr group from T1 to T2. Our results indicate that Cr supplementation alters the metabolic response during sustained high-intensity submaximal exercise. Plasma data suggest that nett intramuscular adenine nucleotide degradation may be decreased in the presence of enhanced intramuscular TCr concentration even during submaximal exercise.
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