Dietary supplementation with eicosapentaenoic acid, but not with other long-chain n-3 or n-6 polyunsaturated fatty acids, decreases natural killer cell activity in healthy subjects aged >55 y
Thies F, Nebe-von-Caron G, Powell JR, Yaqoob P, Newsholme EA, Calder PC
The American journal of clinical nutrition · 128 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2001-03-01 · Am J Clin Nutr · vol. 73 · número 3 · págs. 539–548
- Editorial
- Elsevier BV
- Citado
- 199 citas · más que el 99% de estudios similares · 11.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 50 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Edible Oils Quality and Analysis · Aquaculture Nutrition and Growth
- Palabras clave
- eicosapentaenoic acid, n-3 long-chain polyunsaturated fatty acids, omega-6 fatty acids, NK cell cytotoxicity, dietary fatty acid supplementation, fish oil, linseed oil, evening primrose oil, alpha-linolenic acid, gamma-linolenic acid, arachidonic acid, docosahexaenoic acid, older adults, immune function
- MeSH
- killer cells, natural, lymphocyte subsets, humans, fatty acids, omega-3, alpha-linolenic acid, docosahexaenoic acids, eicosapentaenoic acid, fatty acids, unsaturated, arachidonic acid, gamma-linolenic acid, fatty acids, omega-6, fish oils, double-blind method, immunity, cellular, time factors, dietary supplements, aged, middle aged, female, male
6 autores
- Frank Thiès🇬🇧Unilever (United Kingdom); University of Oxford; University of Southampton; University of Reading
- Gerhard Nebe‐von‐Caron🇬🇧Unilever (United Kingdom); University of Oxford; University of Southampton; University of Reading
- Jonathan R. Powell🇬🇧Unilever (United Kingdom); University of Oxford; University of Southampton; University of Reading
- Parveen Yaqoob🇬🇧Unilever (United Kingdom); University of Oxford; University of Southampton; University of Reading
- Eric A. Newsholme🇬🇧Unilever (United Kingdom); University of Oxford; University of Southampton; University of Reading
- Philip C. Calder🇬🇧 · autor de correspondenciaUnilever (United Kingdom); University of Oxford; University of Southampton; University of Reading
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Animal studies showed that dietary flaxseed oil [rich in the n-3 polyunsaturated fatty acid alpha-linolenic acid (ALA)], evening primrose oil [rich in the n-6 polyunsaturated fatty acid gamma-linolenic acid (GLA)], and fish oil [rich in the long-chain n-3 polyunsaturated fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)] can decrease natural killer (NK) cell activity. There have been no studies of the effect on NK cell activity of adding these oils to the diet of humans.
Objective
Our objective was to determine the effect of dietary supplementation with oil blends rich in ALA, GLA, arachidonic acid (AA), DHA, or EPA plus DHA (fish oil) on the NK cell activity of human peripheral blood mononuclear cells.
Design
A randomized, placebo-controlled, double-blind, parallel study was conducted. Healthy subjects aged 55-75 y consumed 9 capsules/d for 12 wk; the capsules contained placebo oil (an 80:20 mix of palm and sunflower seed oils) or blends of placebo oil and oils rich in ALA, GLA, AA, DHA, or EPA plus DHA. Subjects in these groups consumed 2 g ALA, 770 mg GLA, 680 mg AA, 720 mg DHA, or 1 g EPA plus DHA (720 mg EPA + 280 mg DHA) daily, respectively. Total fat intake from the capsules was 4 g/d.
Results
The fatty acid composition of plasma phospholipids changed significantly in the GLA, AA, DHA, and fish oil groups. NK cell activity was not significantly affected by the placebo, ALA, GLA, AA, or DHA treatment. Fish oil caused a significant reduction (mean decline: 48%) in NK cell activity that was fully reversed by 4 wk after supplementation had ceased.
Conclusion
A moderate amount of EPA but not of other n-6 or n-3 polyunsaturated fatty acids can decrease NK cell activity in healthy subjects.
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