Effects of diets containing olive oil, sunflower oil, or rapeseed oil on the hemostatic system
Junker R, Kratz M, Neufeld M, Erren M, Nofer JR, Schulte H, Nowak-Göttl U, Assmann G, Wahrburg U
Thrombosis and haemostasis · 38 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2001-01-01 · Thromb Haemost · vol. 85 · número 02 · págs. 280–286
- Editorial
- Thieme Medical Publishers (Germany)
- Citado
- 59 citas · más que el 86% de estudios similares · 2.1× el promedio de su campo
- Referencias
- 25 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Blood properties and coagulation · Blood Coagulation and Thrombosis Mechanisms
- Palabras clave
- olive oil, sunflower oil, rapeseed oil, dietary fat, hemostasis, platelet function, coagulation factors, monounsaturated fatty acids, n-3/n-6 PUFA ratio, fibrinogen binding, CD62, spontaneous platelet aggregation, saturated fatty acids
- MeSH
- humans, dietary fats, unsaturated, fatty acids, omega-3, fatty acids, unsaturated, fatty acids, monounsaturated, fatty acids, omega-6, plant oils, factor vii, factor xii, platelet function tests, hemostasis, adult, female, male, olive oil, sunflower oil, rapeseed oil
9 autores
- Mario Kratz🇩🇪University of Münster
- Margitta Neufeld🇩🇪University of Münster
- Michael Erren🇩🇪University of Münster
- Jerzy–Roch Nofer🇩🇪University of Münster
- Helmut Schulte🇩🇪University of Münster
- Ulrike Nowak‐Göttl🇩🇪University of Münster
- Gerd Assmann🇩🇪University of Münster
- Ursel Wahrburg🇩🇪University of Münster
- Ralf Junker🇩🇪University of Münster
Resumen
El texto original del estudio, en el idioma en que se publicó.
Various studies have already shown that the fatty acid composition of dietary fat has different effects on hemostasis and platelet function. However, knowledge on this topic is incomplete. In the present study, fifty-eight healthy students received either a 4-week rapeseed oil [high content of monounsaturated fatty acids (MUFA) and high n-3/n-6 PUFA ratio], an olive oil (high content of MUFA, low n-3/n-6 PUFA ratio) or a sunflower oil (low content of MUFA, low n-3/n-6 PUFA ratio) diet. In each group, effects on hemostatic parameters were compared with a wash-in diet rich in saturated fatty acids with respect to intermediate-time effects on the hemostatic system and platelet function. With the olive oil diet, a reduction of coagulation factors VIIc, XIIc, XIIa, and Xc was found, whereas sunflower oil led to lower values of coagulation factors XIIc, XIIa, and IXc. In all study groups levels of plasmin-alpha2-antiplasmin were lower in week 4 than at baseline. Lower fibrinogen binding on platelets was found after the sunflower oil diet, whereas expression of CD62 and spontaneous platelet aggregation were slightly higher after the olive oil diet. However, given the major differences in the fatty acid compositions of the diets, the differences between the groups with respect to hemostasis tended to be small. Therefore, the clinical significance of the present findings remains to be evaluated.
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