Partially hydrogenated soybean oil reduces postprandial t-PA activity compared with palm oil
Müller H, Seljeflot I, Solvoll K, Pedersen JI
Atherosclerosis · 11 citas
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Alimentación controladaFinanciación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2001-04-01 · Atherosclerosis · vol. 155 · número 2 · págs. 467–476
- Editorial
- Elsevier BV
- Citado
- 23 citas · más que el 87% de estudios similares · 2.1× el promedio de su campo
- Referencias
- 53 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Blood properties and coagulation · Edible Oils Quality and Analysis
- Palabras clave
- partially hydrogenated soybean oil, palm oil, trans fatty acids, tissue plasminogen activator, fibrinolysis, polyunsaturated fatty acids, margarine, diurnal variation, plasminogen activator inhibitor-1, factor VII coagulant activity, fibrinogen, dietary fat
- MeSH
- humans, tissue plasminogen activator, dietary fats, unsaturated, soybean oil, margarine, fatty acids, unsaturated, plant oils, random allocation, feeding behavior, hydrogenation, fibrinolysis, eating, adult, female, palm oil
4 autores
- Hanne Müller🇳🇴OsloMet – Oslo Metropolitan University
- Ingebjørg Seljeflot🇳🇴Oslo University Hospital
- Kari Solvoll🇳🇴University of Oslo
- Jan Ivar Pedersen🇳🇴 · autor de correspondenciaOsloMet – Oslo Metropolitan University; University of Oslo
Resumen
El texto original del estudio, en el idioma en que se publicó.
The effects of dietary trans fatty acids on fasting and diurnal variation in hemostatic variables are not known. This study compares the effects of three diets with three different margarines, one based on palm oil (PALM-diet), one based on partially hydrogenated soybean oil (PHSO, TRANS-diet) and one with a high content of polyunsaturated fatty acids (PUFA-diet) on diurnal postprandial hemostatic variables. A strictly controlled dietary Latin square study was performed and nine young female participants consumed each of the diets for 17 days in a random order. The sum of the cholesterol-increasing fatty acids (C12:0, C14:0, C16:0) was 36.3% of total fatty acids in the PALM-diet, the same as the sum of saturated-(C12:0, C14:0, C16:0) (12.5%) and trans fatty acids (23.1%) in the TRANS-diet. The sum of C12:0, C14:0 and C16:0 was 20.7% in the PUFA-diet. The amount of fat made up 30-31% of energy in all diets. Nine participants completed the study. The diurnal postprandial state level of tissue plasminogen activator (t-PA) activity was significantly decreased on the TRANS-diet compared with the PALM-diet. t-PA activity was also decreased on the PUFA-diet compared with PALM-diet but the difference was below statistical significance (P=0.07, Bonferonni adjusted). There were no significant differences in either fasting levels or in circadian variation of t-PA antigen, PAI-1 activity, PAI-antigen, factor VII coagulant activity or fibrinogen between the three diets. Our results indicate that dietary trans fatty acids from PHSO has an unfavourable effect on postprandial t-PA activity and thus possibly on the fibrinolytic system compared with palm oil.
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