Dietary fat intake and prevention of cardiovascular disease: systematic review
Hooper L, Summerbell CD, Higgins JP, Thompson RL, Capps NE, Smith GD, Riemersma RA, Ebrahim S
BMJ (Clinical research ed.) · 203 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2001-03-31 · BMJ · vol. 322 · número 7289 · págs. 757–763
- Citado
- 390 citas · más que el 98% de estudios similares · 5.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 58 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Nutritional Studies and Diet · Fatty Acid Research and Health · Lipoproteins and Cardiovascular Health
- Palabras clave
- dietary fat intake, cardiovascular disease prevention, cardiovascular mortality, all-cause mortality, cardiovascular morbidity, saturated fat, monounsaturated fatty acids, polyunsaturated fat, cholesterol lowering, serum lipids, oily fish, trial duration
- MeSH
- humans, cardiovascular diseases, cholesterol, dietary fats, risk factors, randomized controlled trials as topic
8 autores
- Lee Hooper🇬🇧 · autor de correspondenciaUniversity Dental Hospital of Manchester
- Carolyn Summerbell🇬🇧University Dental Hospital of Manchester
- Julian P T Higgins
- Rachel L Thompson
- Nigel E. Capps
- George Davey Smith
- Rudolph A Riemersma
- Shah B J Ebrahim
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To assess the effect of reduction or modification of dietary fat intake on total and cardiovascular mortality and cardiovascular morbidity.
Design
Systematic review.
Data sources
Cochrane Library, Medline, Embase, CAB abstracts, SIGLE, CVRCT registry, and biographies were searched; trials known to experts were included.
Included studies
Randomised controlled trials stating intention to reduce or modify fat or cholesterol intake in healthy adult participants over at least six months. Inclusion decisions, validity, and data extraction were duplicated. Meta-analysis (random effects methodology), meta-regression, and funnel plots were performed.
Results
27 studies (30 902 person years of observation) were included. Alteration of dietary fat intake had small effects on total mortality (rate ratio 0.98; 95% confidence interval 0.86 to 1.12). Cardiovascular mortality was reduced by 9% (0.91; 0.77 to 1.07) and cardiovascular events by 16% (0.84; 0.72 to 0.99), which was attenuated (0.86; 0.72 to 1.03) in a sensitivity analysis that excluded a trial using oily fish. Trials with at least two years' follow up provided stronger evidence of protection from cardiovascular events (0.76; 0.65 to 0.90).
Conclusions
There is a small but potentially important reduction in cardiovascular risk with reduction or modification of dietary fat intake, seen particularly in trials of longer duration.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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