Evaluation of electrocardiographic and hemodynamic effects of caffeine with acute dosing in healthy volunteers
Ammar R, Song JC, Kluger J, White CM
Pharmacotherapy · 44 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2001-04-01 · Pharmacotherapy · vol. 21 · número 4 · págs. 437–442
- Editorial
- Wiley
- Citado
- 68 citas · más que el 74% de estudios similares · 0.8× el promedio de su campo
- Referencias
- 26 trabajos
- Acceso
- De pago
- Áreas de investigación
- Coffee research and impacts · Cardiac electrophysiology and arrhythmias · Blood Pressure and Hypertension Studies
- Palabras clave
- caffeine, acute caffeine ingestion, electrocardiographic changes, QT interval, QTc interval, QT dispersion, RR interval, blood pressure, heart rate, caffeine abstinence, healthy young adults
- MeSH
- humans, caffeine, central nervous system stimulants, electrocardiography, administration, oral, cross-over studies, double-blind method, half-life, adult, female, male, hemodynamics
4 autores
- Rabab Ammar🇺🇸University of Connecticut
- Jessica Song🇺🇸Hartford Hospital; University of Connecticut
- Jeffrey Kluger🇺🇸Hartford Hospital; University of Connecticut; UConn Health
- Charles Michael White🇺🇸 · autor de correspondenciaHartford Hospital; University of Connecticut
Resumen
El texto original del estudio, en el idioma en que se publicó.
Study objective
To evaluate the effects of moderate, single-dose caffeine consumption on electrocardiographic variables: PR, QRS, QT, QTc, and RR intervals, and QT and QTc interval dispersion. Effects of caffeine on blood pressure and heart rate also were evaluated.
Design
Randomized, double-blind, placebo-controlled, crossover study.
Setting
University school of pharmacy.
Patients
Ten healthy volunteers aged 17 years or older.
Intervention
Participants abstained from caffeinated products for at least 2 days before the study began and were randomly designated to receive placebo or caffeine 400 mg on various days. For each of the study phases, a baseline 12-lead electrocardiogram (ECG) was performed and a subsequent 12-lead ECG performed 3 hours after ingesting the study drug. Blood pressure readings were taken with each ECG.
Measurements and main results
No significant changes in any intragroup or intergroup electrocardiographic variables occurred. Caffeine increased blood pressure (systolic blood pressure [SBP]/diastolic blood pressure [DBP]) from 118+/-5/75+/-6 mm Hg to 128+/-8/77+/-7 mm Hg versus baseline (p=0.0022 and p=0.0368 for SBP and DBP, respectively). After drug dosing, SBP in the caffeine group was significantly higher than in the placebo group (128+/-8 mm Hg versus 119+/-7 mm Hg, p=0.0174).
Conclusion
Moderate caffeine consumption by healthy young adults does not acutely affect PR, QRS, QT, QTc, and RR intervals, or QT and QTc interval dispersion. Caffeine-naive subjects experienced persistent elevations in SBP and DBP 3 hours after caffeine ingestion, indicating that longer caffeine abstinence than that which is recommended is necessary for blood pressure determination in the clinical setting.
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