Insulin resistance, dietary cholesterol, and cholesterol concentration in postmenopausal women
Reaven GM, Abbasi F, Bernhart S, Coulston A, Darnell B, Dashti N, Kim H, Kulkarni K, Lamendola C, McLaughlin T, Osterlund L, Schaff P, Segrest J
Metabolism: clinical and experimental · 21 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Center for Research Resources
- Gobierno
- NCRR NIH HHS
- Subvenciones
- National Center for Research Resources (RR 00 070); National Center for Research Resources (RR 00032)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2001-05-01 · Metabolism · vol. 50 · número 5 · págs. 594–597
- Editorial
- Elsevier BV
- Citado
- 31 citas · más que el 72% de estudios similares · 0.6× el promedio de su campo
- Referencias
- 17 trabajos
- Acceso
- De pago
- Áreas de investigación
- Cholesterol and Lipid Metabolism · Lipoproteins and Cardiovascular Health · Nutritional Studies and Diet
- Palabras clave
- insulin resistance, dietary cholesterol, serum cholesterol, LDL cholesterol, postmenopausal women, glucose disposal, dietary intervention, hypercholesterolemia
- MeSH
- humans, insulin resistance, cholesterol, lipids, cholesterol, dietary, triglycerides, lipoproteins, lipoprotein(a), apolipoproteins a, apolipoproteins b, body mass index, postmenopause, middle aged, female, cholesterol, ldl, cholesterol, hdl, cholesterol, vldl
13 autores
- Gerald M. Reaven🇺🇸University of Alabama at Birmingham; Stanford Medicine; Stanford University
- Fahim Abbasi🇺🇸University of Alabama at Birmingham; Stanford Medicine; Stanford University
- S. Bernhart🇺🇸University of Alabama at Birmingham; Stanford Medicine; Stanford University
- Ann M. Coulston🇺🇸University of Alabama at Birmingham; Stanford Medicine; Stanford University
- Betty E. Darnell🇺🇸University of Alabama at Birmingham; Stanford Medicine; Stanford University
- Nassrin Dashti🇺🇸University of Alabama at Birmingham; Stanford Medicine; Stanford University
- H.-S. Kim🇺🇸University of Alabama at Birmingham; Stanford Medicine; Stanford University
- Ketaki Yogesh Kulkarni🇺🇸University of Alabama at Birmingham; Stanford Medicine; Stanford University
- Cindy A. Lamendola🇺🇸University of Alabama at Birmingham; Stanford Medicine; Stanford University
- Tracey McLaughlin🇺🇸University of Alabama at Birmingham; Stanford Medicine; Stanford University
- Laura Osterlund🇺🇸University of Alabama at Birmingham; Stanford Medicine; Stanford University
- Patricia Schaaf🇺🇸University of Alabama at Birmingham; Stanford Medicine; Stanford University
- Jere P. Segrest🇺🇸University of Alabama at Birmingham; Stanford Medicine; Stanford University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Questions remain concerning the effect of variations in cholesterol intake on plasma cholesterol concentration, as well as on the role of factors modulating the metabolic impact of this dietary intervention. To define the impact of wide variations in dietary cholesterol intake on plasma total and low-density lipoprotein (LDL) cholesterol concentrations, as well as testing the hypothesis that resistance to insulin-mediated glucose disposal would accentuate the increase in plasma total and LDL cholesterol concentrations in response to a given increment in dietary cholesterol intake, we performed a prospective, randomized study comparing diets varying in cholesterol content in 65 healthy, postmenopausal women, 31 defined as insulin-resistant and 34 as insulin-sensitive. The changes in total and LDL cholesterol in response to increments in dietary cholesterol of up to approximately 800 mg/day were modest in magnitude, without evidence of a statistically significant diet-induced increase in cholesterol concentration, or of any difference in the responses of insulin-resistant as compared with insulin-sensitive women. These results indicate that relatively large increments in dietary cholesterol intake had little effect on total or LDL cholesterol concentrations in healthy, postmenopausal women, irrespective of whether they were insulin-resistant or insulin-sensitive.
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