Dietary supplementation with gamma-linolenic acid or fish oil decreases T lymphocyte proliferation in healthy older humans
Thies F, Nebe-von-Caron G, Powell JR, Yaqoob P, Newsholme EA, Calder PC
The Journal of nutrition · 152 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2001-07-01 · J Nutr · vol. 131 · número 7 · págs. 1918–1927
- Editorial
- Elsevier BV
- Citado
- 232 citas · más que el 99% de estudios similares · 12.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 52 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Edible Oils Quality and Analysis · Aquaculture Nutrition and Growth
- Palabras clave
- gamma-linolenic acid, fish oil, dietary supplementation, T cell proliferation, peripheral blood mononuclear cells, omega-3 fatty acids, arachidonic acid, docosahexaenoic acid, eicosapentaenoic acid, interleukin-2, interferon-gamma, lymphocyte subsets, phospholipid fatty acid composition, older adults, immunomodulation
- MeSH
- leukocytes, mononuclear, lymphocyte subsets, humans, alpha-linolenic acid, docosahexaenoic acids, arachidonic acid, gamma-linolenic acid, fish oils, interleukin-2, double-blind method, lymphocyte activation, cell division, dietary supplements, aged, middle aged, female, male, interferon-gamma
6 autores
- Frank Thiès🇬🇧University of Oxford
- Gerhard Nebe‐von‐Caron🇬🇧Unilever (United Kingdom)
- Jonathan R. Powell🇬🇧Unilever (United Kingdom)
- Parveen Yaqoob🇬🇧University of Reading
- E.A. Newsholme🇬🇧University of Oxford
- Philip C. Calder🇬🇧 · autor de correspondenciaUniversity of Southampton
Resumen
El texto original del estudio, en el idioma en que se publicó.
Animal and human studies have shown that greatly increasing the amounts of flax seed oil [rich in the (n-3) polyunsaturated fatty acid (PUFA) alpha-linolenic acid (ALNA)] or fish oil [FO; rich in the long chain (n-3) PUFA eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)] in the diet can decrease mitogen-stimulated lymphocyte proliferation. The objective of this study was to determine the effect of dietary supplementation with moderate levels of ALNA, gamma-linolenic acid (GLA), arachidonic acid (ARA), DHA or FO on the proliferation of mitogen-stimulated human peripheral blood mononuclear cells (PBMC) and on the production of cytokines by those cells. The study was randomized, placebo-controlled, double-blinded and parallel. Healthy subjects ages 55-75 y consumed nine capsules/d for 12 wk; the capsules contained placebo oil (an 80:20 mix of palm and sunflower seed oils) or blends of placebo oil with oils rich in ALNA, GLA, ARA or DHA or FO. Subjects in these groups consumed 2 g of ALNA or 770 mg of GLA or 680 mg of ARA or 720 mg of DHA or 1 g of EPA plus DHA (720 mg of EPA + 280 mg of DHA) daily from the capsules. Total fat intake from the capsules was 4 g/d. The fatty acid composition of PBMC phospholipids was significantly changed in the GLA, ARA, DHA and FO groups. Lymphocyte proliferation was not significantly affected by the placebo, ALNA, ARA or DHA treatments. GLA and FO caused a significant decrease (up to 65%) in lymphocyte proliferation. This decrease was partly reversed by 4 wk after stopping the supplementation. None of the treatments affected the production of interleukin-2 or interferon-gamma by PBMC and none of the treatments affected the number or proportion of T or B lymphocytes, helper or cytotoxic T lymphocytes or memory helper T lymphocytes in the circulation. We conclude that a moderate level GLA or EPA but not of other (n-6) or (n-3) PUFA can decrease lymphocyte proliferation but not production of interleukin-2 or interferon-gamma.
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