A randomized, double-blind, placebo-controlled trial of docosahexaenoic acid supplementation in children with attention-deficit/hyperactivity disorder
Voigt RG, Llorente AM, Jensen CL, Fraley JK, Berretta MC, Heird WC
The Journal of pediatrics · 171 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2001-08-01 · J Pediatr · vol. 139 · número 2 · págs. 189–196
- Editorial
- Elsevier BV
- Citado
- 365 citas · más que el 98% de estudios similares · 9.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 48 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Attention Deficit Hyperactivity Disorder · Vitamin D Research Studies
- Palabras clave
- docosahexaenoic acid, omega-3 supplementation, attention deficit hyperactivity disorder, children, plasma phospholipid fatty acids, inattention, impulsivity, stimulant medication, dietary intervention
- MeSH
- humans, docosahexaenoic acids, phospholipids, analysis of variance, double-blind method, child behavior, attention deficit disorder with hyperactivity, child, female, male
6 autores
- Robert G. Voigt🇺🇸Mayo Clinic; Baylor College of Medicine
- Antolin M. Llorente🇺🇸Agricultural Research Service; Mayo Clinic; Baylor College of Medicine; Children's Nutrition Research Center at Baylor College of Medicine
- Craig L. Jensen🇺🇸Agricultural Research Service; Mayo Clinic; Baylor College of Medicine; Children's Nutrition Research Center at Baylor College of Medicine
- J. Kennard Fraley🇺🇸Agricultural Research Service; Mayo Clinic; Baylor College of Medicine; Children's Nutrition Research Center at Baylor College of Medicine
- Marcia C. Berretta🇺🇸Agricultural Research Service; Mayo Clinic; Baylor College of Medicine; Children's Nutrition Research Center at Baylor College of Medicine
- William C. Heird🇺🇸Agricultural Research Service; Mayo Clinic; Baylor College of Medicine; Children's Nutrition Research Center at Baylor College of Medicine
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To determine whether docosahexaenoic acid (DHA) supplementation for 4 months decreases the symptoms of attention-deficit/hyperactivity disorder (ADHD).
Study design
Sixty-three 6- to-12-year-old children with ADHD, all receiving effective maintenance therapy with stimulant medication, were assigned randomly, in a double-blind fashion, to receive DHA supplementation (345 mg/d) or placebo for 4 months. Outcome variables included plasma phospholipid fatty acid patterns, scores on laboratory measures of inattention and impulsivity (Test of Variables of Attention, Children's Color Trails test) while not taking stimulant medication, and scores on parental behavioral rating scales (Child Behavior Checklist, Conners' Rating Scale). Differences between groups after 4 months of DHA supplementation or placebo administration were determined by analysis of variance, controlling for age, baseline value of each outcome variable, ethnicity, and ADHD subtype.
Results
Plasma phospholipid DHA content of the DHA-supplemented group was 2.6-fold higher at the end of the study than that of the placebo group (4.85 +/- 1.35 vs 1.86 +/- 0.87 mol % of total fatty acids; P <.001). Despite this, there was no statistically significant improvement in any objective or subjective measure of ADHD symptoms.
Conclusion
A 4-month period of DHA supplementation (345 mg/d) does not decrease symptoms of ADHD.
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