Effects of acute creatine monohydrate supplementation on leucine kinetics and mixed-muscle protein synthesis
Parise G, Mihic S, MacLennan D, Yarasheski KE, Tarnopolsky MA
Journal of applied physiology (Bethesda, Md. : 1985) · 147 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- National Center for Research Resources
- Gobierno
- NIDDK NIH HHS
- Gobierno
- NCRR NIH HHS
- Subvenciones
- National Center for Research Resources (P41-RR000954); National Institute of Diabetes and Digestive and Kidney Diseases (DK-54163); National Institute of Diabetes and Digestive and Kidney Diseases (DK49393)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2001-09-01 · J Appl Physiol (1985) · vol. 91 · número 3 · págs. 1041–1047
- Editorial
- American Physiological Society
- Citado
- 235 citas · más que el 95% de estudios similares · 4.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 34 trabajos
- Acceso
- De pago
- Áreas de investigación
- Muscle metabolism and nutrition · Biochemical effects in animals · Nutrition and Health in Aging
- Palabras clave
- creatine monohydrate supplementation, leucine kinetics, protein turnover, leucine oxidation, creatine, fat-free mass, sex differences
- MeSH
- muscle, skeletal, humans, nitrogen, carbon isotopes, creatine, urea, creatinine, leucine, phosphocreatine, muscle proteins, adenosine triphosphate, double-blind method, body composition, sex characteristics, kinetics, dietary supplements, adult, female, male, mass spectrometry
5 autores
- Gianni Parise
- S. Mihic
- D. MacLennan
- Kevin E. Yarasheski🇺🇸Washington University in St. Louis
- Mark Andrew Tarnopolsky🇨🇦McMaster University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Creatine monohydrate (CrM) supplementation during resistance exercise training results in a greater increase in strength and fat-free mass than placebo. Whether this is solely due to an increase in intracellular water or whether there may be alterations in protein turnover is not clear at this point. We examined the effects of CrM supplementation on indexes of protein metabolism in young healthy men (n = 13) and women (n = 14). Subjects were randomly allocated to CrM (20 g/day for 5 days followed by 5 g/day for 3-4 days) or placebo (glucose polymers) and tested before and after the supplementation period under rigorous dietary and exercise controls. Muscle phosphocreatine, creatine, and total creatine were measured before and after supplementation. A primed-continuous intravenous infusion of L-[1-(13)C]leucine and mass spectrometry were used to measure mixed-muscle protein fractional synthetic rate and indexes of whole body leucine metabolism (nonoxidative leucine disposal), leucine oxidation, and plasma leucine rate of appearance. CrM supplementation increased muscle total creatine (+13.1%, P < 0.05) with a trend toward an increase in phosphocreatine (+8.8%, P = 0.09). CrM supplementation did not increase muscle fractional synthetic rate but reduced leucine oxidation (-19.6%) and plasma leucine rate of appearance (-7.5%, P < 0.05) in men, but not in women. CrM did not increase total body mass or fat-free mass. We conclude that short-term CrM supplementation may have anticatabolic actions in some proteins (in men), but CrM does not increase whole body or mixed-muscle protein synthesis.
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