The value of serum albumin and high-density lipoprotein cholesterol in defining mortality risk in older persons with low serum cholesterol
Volpato S, Leveille SG, Corti MC, Harris TB, Guralnik JM
Journal of the American Geriatrics Society · 86 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2001-09-01 · J Am Geriatr Soc · vol. 49 · número 9 · págs. 1142–1147
- Editorial
- Wiley
- Citado
- 114 citas · más que el 94% de estudios similares · 4.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 38 trabajos
- Acceso
- De pago
- Áreas de investigación
- Lipoproteins and Cardiovascular Health · Nutrition and Health in Aging · Cholesterol and Lipid Metabolism
- Palabras clave
- low serum cholesterol, serum albumin, HDL cholesterol, mortality risk, older adults, all-cause mortality, non-cardiovascular mortality, prognostic subgroups, low HDL cholesterol, low albumin, cardiovascular risk stratification, coronary artery disease, ischemic stroke
- MeSH
- humans, cholesterol, serum albumin, mortality, cause of death, multivariate analysis, proportional hazards models, risk, survival analysis, prospective studies, algorithms, aged, aged, 80 and over, iowa, connecticut, boston, female, male, cholesterol, hdl
5 autores
- Stefano Volpato🇺🇸 · autor de correspondenciaNational Institutes of Health; National Institute on Aging
- Suzanne G. Leveille
- Maria‐Chiara Corti
- Tamara B. Harris🇺🇸National Institutes of Health; National Institute on Aging
- Jack M. Guralnik🇺🇸National Institutes of Health; National Institute on Aging
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
To investigate the relationship between low cholesterol and mortality in older persons to identify, using information collected at a single point in time, subgroups of persons with low and high mortality risk.
Design
Prospective cohort study with a median follow-up period of 4.9 years.
Settings
East Boston, Massachusetts; New Haven, Connecticut; and Iowa and Washington counties, Iowa.
Participants
Four thousand one hundred twenty-eight participants (64% women) age 70 and older at baseline (mean 78.7 years, range 70-103); 393 (9.5%) had low cholesterol, defined as < or =160 mg/dl.
Measurements
All-cause mortality and mortality not related to coronary heart disease and ischemic stroke.
Results
During the follow-up period there were 1,117 deaths. After adjustment for age and gender, persons with low cholesterol had significantly higher mortality than those with normal and high cholesterol. Among subjects with low cholesterol, those with albumin> 38 g/L had a significant risk reduction compared with those with albumin or =47 mg/dl had a 62% risk reduction (RR = 0.38; 95% CI = 0.20-0.68), compared with the reference category; those with albumin < or =38 g/L and HDL-C <47 mg/dl.
Conclusions
Older persons with low cholesterol constitute a heterogeneous group with regard to health characteristics and mortality risk. Serum albumin and HDL-C can be routinely used in older patients with low cholesterol to distinguish three subgroups with different prognoses: (1) high risk (low albumin), (2) intermediate risk (high albumin and low HDL-C), and (3) low risk (high albumin and high HDL-C).
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