Effects of oral creatine and resistance training on myosin heavy chain expression
Willoughby DS, Rosene J
Medicine and science in sports and exercise · 103 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2001-10-01 · Med Sci Sports Exerc · vol. 33 · número 10 · págs. 1674–1681
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 209 citas · más que el 95% de estudios similares · 4.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 33 trabajos
- Acceso
- De pago
- Áreas de investigación
- Muscle metabolism and nutrition · Muscle Physiology and Disorders · Sports Performance and Training
- Palabras clave
- creatine supplementation, resistance training, myosin heavy chain isoforms, muscle strength, muscle hypertrophy, fat-free mass, untrained men, muscle fiber type
- MeSH
- myofibrils, muscle, skeletal, humans, creatine, muscle proteins, myosin heavy chains, rna, messenger, anthropometry, administration, oral, analysis of variance, double-blind method, gene expression, body composition, time factors, physical education and training, dietary supplements, adult, male
2 autores
- Darryn S. Willoughby🇺🇸Texas Christian University
- John M. Rosene🇺🇸University of Hawaiʻi at Mānoa; Texas Christian University; University of Hawaii System
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
This study examined 12 wk of creatine (Cr) supplementation and heavy resistance training on muscle strength and myosin heavy chain (MHC) isoform mRNA and protein expression.
Methods
Twenty-two untrained male subjects were randomly assigned to either a control (CON), placebo (PLC), or Cr (CRT) group in a double-blind fashion. Muscle biopsies were obtained before and after 12 wk of heavy resistance training. PLC and CRT trained thrice weekly using three sets of 6-8 repetitions at 85-90% 1-RM on the leg press, knee extension, and knee curl exercises. CRT ingested 6 g.d-1 of Cr for 12 wk, whereas PLC consumed the equal concentration of placebo.
Results
There were no significant differences for percent body fat (P > 0.05). However, for total body mass, fat-free mass, thigh volume, muscle strength, and myofibrillar protein, CRT and PLC exhibited significant increases after training when compared to CON (P < 0.05), whereas CRT was also significantly greater than PLC (P < 0.05). For Type I, IIa, and IIx MHC mRNA expression, CRT was significantly greater than CON and PLC, whereas PLC was greater than CON (P < 0.05). For MHC protein expression, CRT was significantly greater than CON and PLC for Type I and IIx (P < 0.05) but was equal to PLC for IIa.
Conclusion
Long-term Cr supplementation increases muscle strength and size, possibly as a result of increased MHC synthesis.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.