A diet containing rapeseed oil-based fats does not increase lipid peroxidation in humans when compared to a diet rich in saturated fatty acids
Södergren E, Gustafsson IB, Basu S, Nourooz-Zadeh J, Nälsén C, Turpeinen A, Berglund L, Vessby B
European journal of clinical nutrition · 39 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Skogs- och Jordbrukets Forskningsråd
Según 1 financiador declarado.
Publicación
- Publicado
- 2001-10-25 · Eur J Clin Nutr · vol. 55 · número 11 · págs. 922–931
- Editorial
- Springer Nature
- Citado
- 53 citas · más que el 71% de estudios similares · 0.6× el promedio de su campo
- Referencias
- 50 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Antioxidant Activity and Oxidative Stress · Edible Oils Quality and Analysis
- Palabras clave
- rapeseed oil, alpha-linolenic acid, polyunsaturated fatty acids, saturated fatty acids, lipid peroxidation, 8-isoprostane, malondialdehyde, hydroperoxides, gamma-tocopherol, alpha-tocopherol, antioxidant capacity, hyperlipidemia, LDL cholesterol, dietary fat
- MeSH
- humans, lipid peroxides, dietary fats, fatty acids, fatty acids, unsaturated, fatty acids, monounsaturated, lipoproteins, plant oils, antioxidants, diet, cross-over studies, oxidation-reduction, lipid peroxidation, middle aged, female, male, biomarkers, rapeseed oil
8 autores
- Erica Sodergren🇸🇪Uppsala University
- I B Gustafsson🇸🇪Örebro University
- S Basu🇸🇪Uppsala University
- Jaffar Nourooz‐Zadeh🇬🇧University College London
- Cecilia Nälsén🇸🇪Uppsala University
- Anu M. Turpeinen🇫🇮University of Helsinki
- Lars Berglund🇸🇪Uppsala University
- B. Vessby🇸🇪Uppsala University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To compare the effects of a rapeseed oil-based diet containing an increased proportion of easily oxidised polyunsaturated fatty acids such as alpha-linolenic acid with a diet rich in saturated fatty acids on the degree of lipid peroxidation in the human body.
Design
A randomised cross-over study.
Subjects and interventions
Nineteen healthy moderately hyperlipidemic subjects (six women and 13 men, age 50+/-8 y and body mass index (BMI) 24.5+/-2.6 kg/m(2)) were given a rapeseed oil-based diet (RO) and a control diet (SAT) rich in saturated fatty acids during two consecutive 4 week periods separated by a 4 week wash-out period. Biomarkers of lipid peroxidation and antioxidants were analysed in plasma and urine.
Results
No significant differences in plasma or urinary levels of free 8-iso-prostaglandin F(2alpha), plasma total 8-iso-prostaglandin F(2alpha) plasma hydroperoxides or plasma malondialdehyde were observed between the RO and SAT diets (P=0.14-0.95). A higher concentration of serum gamma-tocopherol was detected after the RO diet compared to the SAT diet (P<0.001), whereas the serum alpha-tocopherol concentration and plasma antioxidative capacity did not differ between the two test diets. The total cholesterol, LDL cholesterol and LDL/HDL ratio were lower after the RO diet compared to the SAT diet (P<0.001), while HDL cholesterol and total triglyceride levels were similar after the two diets.
Conclusion
These results suggest that a rapeseed oil-based diet rich in alpha-linolenic acid does not seem to increase the degree of lipid peroxidation in plasma and urine compared to a diet rich in saturated fats. This is possibly due to a sufficient content of antioxidants in the rapeseed oil diet to increase circulating concentrations of antioxidants that may protect unsaturated fatty acids from oxidation.
Sponsorship
Swedish Council for Forestry and Agricultural Research and Foundation for Geriatric Research.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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